Prevalence Of Adverse Events Related To Blood Transfusion At Tertiary Care Center Of Central India.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Background: Although blood transfusion is an essential part of medical treatment but it is also associated with significant clinical risks due to blood components’ allogenic origin. In recent testing facilities have lowered the incidence of transfusion-transmitted Infections (TTIs) to minimum; however, the incidence of adverse events due to human errors, ABO incompatibility, alloimmunization, bacterial contamination, and immunomodulation phenomena remain a matter of concern. Aim of study: Present study was aimed to determine the frequency and types of NIATRs occurring in hospitalized patients at a tertiary care hospital in central India and its comparison with related study from India and abroad. Place of duration of study: A 10 years retrospective cross sectional study was carried out at the Blood Bank, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India from 1st January 2007 t0 31st December 2016. Methodology: All data relating to blood donors, blood units, transfusion of blood/components and adverse events of transfusion were assessed, calculated, compiled, tabulated and was discussed in the study. Data has been compared statistically by frequency distribution and percentage proportion. Chi square (X2) test was applied to know the significant (p value) ratio of difference statistically. Results: Prevalence of NIATRs in the study was 3.4% (n= 6213/181106). Most commonly Prevalent transfusion reaction was AR 1.56% followed by FNHTR 0.92 %, DHT, 0.46, TACO 0.45%, BS 0.02%, AI 0.005%, AHTR 0.004%, and others 0.003%. Amongst the all transfusion reactions, most frequent transfusion reaction was AR 45.45% followed by FNHTR 26.83 %, DHTR 13.52%, TACO 13.06% , BS 0.74%, AI 0.16%, AHTR 0.13% , and others 0.096% Distribution is statistically significant (p=.000002). Conclusion: We concluded that prevalence of NIATRs at our institute was 3.4%. Clinical features of adverse events are range from mild to severe. Rational use of blood components and Proper implementation of hemovigilance programme at national level is need of the hour to prevent / or minimize the adverse events related to blood transfusion.
Authors and Affiliations
Dr. Sachin Singhal, Dr. Anita arya, Dr. Dharmesh Chandra Sharma, Dr. Megha Goyal, Dr Jyoti Bindal, Dr. Bharat Jain
Keywords
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