Prevalence of antibiotic sensitivity pattern of uropathogens in patients of different age-groups from western region of Nepal
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 9
Abstract
UTI, the most common bacterial infection in urinary tract, is a serious health- problem that occurs in millions of people at any age in each year. Its empirical treatment is difficult worldwide. Local susceptibility-pattern of uropathogens is, therefore, important. To determine prevalence of UTI-associated uropathogens and their antibacterial sensitivity-pattern. The midstream urine samples were collected from patients of different age-groups, followed by examination with semi-quantitative culture method and determination of antibacterial sensitivitypatterns using Kirby-Bauer disc diffusion technique. Data were analyzed in MS-Excel, 2007, and chi-square was used to test the significance. Out of 4872 samples, 34 % showed significant growth of pathogens. The patients were from newborn to 80-years-old. Majority of UTI (55.2 %) were from middle-aged patients with 20-49 years-old and 83.9 % organisms were isolated from females. The gram-negative aerobic rods accounted for 83.11 % prevalence and that of gram-positive was 16.88 %. The infections caused by E. coli (44.33 %), Klebsiella spp. (28.23 %), S. saprophyticus (8.32 %), and S. aureus (6.27 %) were prevalent in middle-aged females. These females were markedly associated with pathogens (χ2=25.14, p<0.001). The drugs such as levofloxacin, ofloxacin, ciprofloxacin, ceftriaxone and cefotaxime were five most sensitive antibiotics. Conclusion: Out of 4872 samples, 34 % showed significant growth. Females were markedly associated with pathogens (χ2=25.14, p<0.001). The infections caused by E. coli, Klebsiella spp., S. saprophyticus and S. aureus were predominant and drugs like levofloxacin, ofloxacin, ciprofloxacin, ceftriaxone and cefotaxime the sensitive antibiotics.
Authors and Affiliations
Singh Randhir K| Department of Microbiology, Birat Medical College and Teaching Hospital, Biratnagar, Nepal, Dewasy Bijoylakshmi| Department of Microbiology, Birat Medical College and Teaching Hospital, Biratnagar, Nepal, Mallick Ram L| Department of Biochemistry, Birat Medical College and Teaching Hospital, Biratnagar, Nepal, Kafle Tara K| Department of Community Medicine, Birat Medical College and Teaching Hosptial, Biratnagar, Nepal
Keywords
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