Prevalence of Aspirin Resistance in Patients with Ischemic Stroke at a Tertiary Care Center in North India
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
Background: Ischemic strokes are one of the leading causes of morbidity and mortality now days. Problem increases further if stroke is recurrent. Therefore alongside of acute stroke management, secondary prophylaxis is veryimportant. As for as drugs are concerned aspirin is the most common drug used for the secondary prophylaxis. Despite of these various measures there are recurrences in many patients. Many factors have been held responsiblefor causing such recurrences and aspirin resistance is one of them. Aim: The aim of this study was to assess the prevalence of aspirin resistance in patients with ischemic stroke. Material and Method: This study was conducted in the ischemic stroke patients admitted to the Department of Medicine, King George’s Medical University, Lucknow over a period of One year. The study comprised of 76 consecutive patients of ischemic stroke admitted in our wards. All patients with ischemic stroke (acute/recurrent) received standard treatment with non-enteric coated Aspirin 150 mg per day (supervised) at least for 7 days after which study for platelet function to assess aspirin resistance was performed. Result: Prevalence of Aspirin resistance in our study was found to be 23.7% and this was more prevalent among elderly patients. Conclusion: Based on results of this study we concluded that aspirin resistance does exist. However in absence of any standard definition and gold standard tests exact prevalence and its role in stroke recurrence is still a matter of research.
Authors and Affiliations
Singh S Laxmi
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