Prevalence of Candida Species among HIV Positive Patients in Two Tertiary Hospitals in Rivers State
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Rosuvastatin is a member of the drug class statins, used to treat high cholesterol and to prevent cardiovascular disease. It comes under class II of Biopharmaceutical Classification System. The objective of present study is to develop Rosuvastatin immediate release tablets 10 mg using different types of superdisintegrants to enhance the disintegration time and dissolution of Rosuvastatin calcium to improve bioavailability of the drug. In the present study immediate release formulation of Rosuvastatin calcium was prepared by wet granulation method that are cost effective. Different formulations were made by using various concentrations of superdisintegrants such as Crospovidone, Sodium Starch Glycolate and Kyron T-314 (Polacrillin Potassium). The Prepared formulations were evaluated for the physical characteristics, in vitro dissolution and stability at 40°C/ 75% RH for six months. Among all the formulations F2 (containing 4.5% of super disintegrants i.e., crospovidone) was considered to be the best formulation, which releases up to 102.4% drug in 30 minutes. From this study we can conclude that, formulated tablets of Rosuvastatin containing crospovidone are better and effective than conventional tablets to meet patient compliance.
Authors and Affiliations
Netish Kumar Kundo, Sumon Kumar Dutta2, Abinash Chandro Sarker, Chand Sultana1, Md. Anwarul Haque, Dr. Md. Nurul Islam, Mohammad Mosleh Uddin5
Keywords
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- EP ID EP386357
- DOI 10.9790/3008-1105030105
- Views 122
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