Prevalence of ESBL Production in Gram Negative Isolates in a Tertiary Care Hospital in Gulbarga
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2014, Vol 9, Issue 1
Abstract
Extended Spectrum Beta lactamases are enzymes that mediate resistance to third generation Cephalosporins rendering treatment with these antibiotics ineffective. Bacterial strains that produce these enzymes pose various problems in the management of infectious diseases. With this objective in mind, a total of 272 gram negative, clinical isolates were initially screened for ESBL production, and then confirmed by CLSI confirmatory method. Of the 231 screen positive (85%) isolates, 151 (56%) were confirmed as ESBL positive. Among these, ESBL production was 72% in Klebsiella, 56% in Ecoli, 24% in Citrobacter, 29% in Proteus, 5% in Enterobacter, 15% in Pseudomonas and 33% in Acinetobacter. Considering the statistically significant production of ESBL in these isolates, routine screening of these enzymes is advised in all tertiary care hospitals.
Authors and Affiliations
Sufia M. Siddiqui , Imran N. Khan , Bilal Ahmed , P. Akther
Keywords
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