Prevalence of Gram-negative Pathogens and their antimicrobial susceptibility in bacterial meningitis in pediatric cases
Journal Title: Internet Journal of Medical Update - Year 2012, Vol 7, Issue 2
Abstract
The present study was conducted to find out the prevalence and spectrum of Gram negative pathogens causing bacterial meningitis and their antimicrobial susceptibility pattern in a tertiary care hospital. The cerebrospinal fluid (CSF) (3-5 ml) was collected from 638 admitted children clinically suspected of septic meningitis. Bacterial isolates were identified and antimicrobial susceptibility was assessed by the Kirby-Bauer disk diffusion method. Of the 638 samples tested 102 (15.99%) were culture positive. Male to female (M:F) ratio was 1.62:1. The maximum incidence of 45 (44.12%) cases was found in children (1-12 yrs); in institutional deliveries the incidence was 58 (56.86%) cases. Further, the incidence of 51 cases was found from May to August. Escherichia coli (E. coli) were commonest, seen in 9 (25%) cases followed by Acinetobacter spp., Citrobacter spp. and Klebsiella spp. with 6 (16.67%) cases each. Enterobacter spp., Neisseria spp. and Pseudomonas aeruginosa were isolated in 3 (8.33%) cases each. E. coli, Acinetobacter spp, Citrobacter spp and Klebsiella spp isolates were 100% susceptible to meropenem, piperacillin-tazobactam and cefoperazone-sulbactam and 100% resistant to cotrimoxazole and tetracycline. All strains of Neisseria spp, Enterobacter spp and Pseudomonas spp. were 100% susceptible to meropenem followed by gatifloxacin. These were 100% resistant to tetracycline and cotrimoxazole. Neisseria spp. were also 100% susceptible to pristinamycin. In septic meningitis Gram negative organisms are less common (35.29%). Of the isolates, more common Gram negative isolates included E. coli, Acinetobacter Spp., Citrobacter Spp., and Klebsiella spp. and these isolates were 100% susceptible to meropenem, piperacillin-tazobacatam and cefoperazone-sulbactam. Hence, empirical therapy should be formulated according to antimicrobial susceptibility patterns.
Authors and Affiliations
Yas Chugh, A Kapoor, Anodia Bhargava
Keywords
Related Articles
- EP ID EP140476
- DOI -
- Views 94
- Downloads 0
ISOLATED DISLOCATION OF PISIFORM BONE – A RARE CASE
An isolated dislocation of pisiform bone in a sixteen years male child has been reported here with its clinical presentation, treatment and a brief review of literature. The aim of presenting this case is its rarity due...
Association between different degrees of hypothyroidism and serum lipids
The association between overt hypothyroidism (OH) and altered lipid profile is well known, however the significance of dyslipidemia in subclinical hypothyroidism (SCH) remain controversial. Therefore, this study was cond...
Correlation between hyperuricemia and lipid profile in untreated dyslipidemic patients
There are a number of epidemiological studies that suggest the association of cardiovascular diseases and uric acid but very few studies highlight the direct association of deranged lipid profile with uric acid levels. T...
Fundamentals of Operative Surgery, 1st edition, by Vipul Yagnik
Pattern of gunshot deaths in a Nigerian Tertiary Health Institution
The present study was aimed to determine the pattern of injuries, manner of death, and demographic parameters of gunshot deaths in a Nigerian teaching hospital. This was a prospective descriptive autopsy study of gunshot...