Prevalence of H. pylori Infection and Atrophic Gastritis among dyspeptic subjects in Cameroon using a Panel of Serum Biomarkers (PGI,PGII, G-17, HpIgG)
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 4
Abstract
Abstract: H. pylori infection induces chronic active gastritis that develops with time in a proportion of infected people to atrophic gastritis (AG) and acid free or hypochlorhydric stomach.Objective: Use of a non-invasive serum biomaker test [Pepsinogen-I (PG-I) and -II (PG-II), amidated gastrin-17 (G- 17), and Helicobacter pylori (H.pylori) IgG antibodies], to determine the prevalence of Helicobacter pylori infection and atrophic gastritis (AG), both known to increase the risk of gastric cancer (GC). Subjects consulting for various dyspeptic complaints were prospectively recruited on voluntary basis at the Tombel District Hospital, Yaounde Central Hospital and University Teaching Hospital, from 2008 to 2016. 287 were enrolled 18-84 years (mean±SD 40.08±15.37), including 80 males aged 22-84 years (mean±SD 45.15±15.72) and 207 females aged 18-83 years (mean±SD 46.43±15.24) were examined with a panel of biomarkers. The results were assigned in five categories according to the test panel: 1) Healthy stomach, 2) superficial or non atrophic gastritis associated H. pylori infection, 3) atrophic gastritis (AG) of the corpus, 4) AG of the antrum, and 5) AG of both antrum and corpus (pangastritis). Results: 51 (17.8%) of the subjects were interpreted as normal.226(78.7%) were positive for H. pylori (all cases included), 209 (72.8%) had H pylori-infection (with superficial or no atrophic gastritis). 27 subjects (9.4%) presented with the Gastro Panel results consistent with mucosal atrophy, including atrophic gastritis of the antrum (n=9, 3.1%), corpus, (n=10, 3.5%) or both, pangastritis (n=8, 3.1%). Keywords:Prevalence, H. pylori Infection, Atrophic Gastritis, dyspeptic, Serum Biomarkers
Authors and Affiliations
Ebule I. A, Djune, Fokou, A. K, Sitedjeya, Moko, I. L, Tanni B, Heugueu C, Longdoh A. N, Noah Noah D, OkomoAssoumou M. C
Keywords
Related Articles
- EP ID EP371963
- DOI -
- Views 79
- Downloads 0
A Study on the Outcome of Routine Blood Cultures by Conventional Methods in Relation to the Time of Incubation
Presence of microbes in blood i.e. bacteremia carries high risk of morbidity and mortality. Blood cultures form a critical part of evaluation of patients with suspected sepsis. The present study was undertaken to study t...
Chalk & Board or Power Point Presentation – Students View towards Method of Teaching Anatomy
Abstract: Traditionally most of the lectures are taken with chalk and board in India. However with economic growth, the use of computer assisted techniques is inevitable. The use of power point presentations has been inc...
Surgical Repair Results of CorTriatriatum Sinister in 5 Cases
Abstract: As a rare congenital defect, cortriatriatum sinister represents only 0.1% -0.4% of congenital cardiac anomalies. Depending on the accompanying symptoms and the degree of obstruction, cortriatriatum sinister is...
Sexual and Reproductive Behavior and Reproductive Services Among Nigerian Adolescents
Abstract: This study investigates the relationship between sexual and reproductive health services and sexual and reproductive behavior of adolescents. This is to find out how well the sexual and reproductive health, inc...
A Comparative Study of Drainage of Breast Abscess by Conventional Incision and Drainage versus Percutaneous Placement of Suction Drain
Abstract: Breast abscess is common in puerperal period secondary to mastitis with incidence of 4.8%-11%. The conventional method of incision and drainage of the breast abscess has undergone a gradual change from invasive...