Prevalence of Hyperuricemia and Relation of Serum Uric Acid with Cardiometabolic Risk Factors
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
Cardiometabolic diseases like metabolic syndrome (Mets), cardiovascular disease (CVD) and type 2 diabetes mellitus have several risk factors in common. Several biochemical markers are in current use as laboratory diagnostic aids for these disorders. Many more such markers will emerge in the future as a result of current research. Serum uric acid (SUA) has emerged as a common candidate involved in these three cardiometabolic disorders.The purpose of the present study was to investigate the prevalence of hyperuricemia and the association between uric acid levels and the various cardiometabolic risk factors. This study included 150 cardiometabolic subjects aged 25 to 80 years. The body mass index (BMI), waist circumference, total and HDL cholesterol, serum triglycerides and serum uric acid were measured. Data were analyzed using student t-test, pearson’scoefficient and linear regression model .The prevalence of a serum uric acid level >0.42mmol/L in men was 18.32% and the prevalence of a serum uric acid level >0.36 mmol/L was 15.9% in women. Serum uric acid was strongly related to serum triglycerides in men as well as in women (r = 0.255 in men and r = 0.254 in women, p < 0.001). Uric acid levels were also significantly associated but to a lesser degree with age, BMI and waist circumference. This study shows that serum uric acid is markedly associated with parameters of the metabolic syndrome, in particular serum triglycerides. Considering the growing incidence of obesity and metabolic syndrome worldwide and the potential link between hyperuricemia and cardiovascular complications, more emphasis should be put on the evolving prevalence of hyperuricemia.
Authors and Affiliations
Neha Sharma
Keywords
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