Prevalence of Lung Lesions at Autopsy: A Histopathological Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
Introduction: Autopsies are carried out to establish the identity, cause of death, time of death, and ante-mortem or post-mortem nature of death. These help in establishing the cause of death and ascertain the disease process which led to death. Aim: To study the prevalence and pattern of lung diseases in medicolegal autopsies, confirmed by histopathological examination. Materials and Methods: This retrospective study was carried out in the Department of Pathology. Tissue bits from lungs, retrieved at the time of autopsy, were preserved in 10% formalin. These were processed and examined microscopically. A total of 86 cases were received during the period of study. Results: Among these 86 cases, in 4 cases (4.8%) the tissue was autolysed and in another 26 cases (30.1%) histopathology was unremarkable. Significant microscopic findings were found in 56 cases (65.1%). Wide spectrum of microscopic findings were seen, the commonest being oedema and congestion (28.5%) followed by changes in interstitium (11.9%). There were 9.5% cases of granulomatous inflammation and 5.9% cases each of acute pneumonia and emphysema. There were 1.2% cases each of Hyaline Membrane Disease (HMD), Meconium Aspiration Syndrome (MAS) and Acute Respiratory Distress Syndrome (ARDS) in the series. The series also had 1.2% cases of young adult having fungal colonies surrounded by necrosis and abscess formation. Possibility of mucormycosis was suggested in that case. Conclusion: This study highlights various lesions in lungs confirmed by histopathology, which were either incidental or direct cause of death. The short coming in present study was non receipt of whole organ or representative sample at the time of autopsy, which if overcome will set much higher standard of autopsy reporting and would be a more useful tool in understanding cause of death.
Authors and Affiliations
Pratima Khare, Renu Gupta, Mukta Ahuja, Nupur Khare, Swapnil Agarwal, Deepti Bansal
Keywords
Related Articles
- EP ID EP341872
- DOI 10.7860/JCDR/2017/24747.9827
- Views 102
- Downloads 0
Altered Adaptive Cellular Immune Function in a Group of Egyptian Children with Autism
Introduction: There is a growing evidence of immune system alteration in children with Autism Spectrum Disorder (ASD). These changes may include higher levels of pro-inflammatory cytokines in plasma, Cerebrospinal Fluid...
Unusual Severe Extra-Intestinal Manifestations of a Common Enteric Pathogen-Aeromonas Spp
Introduction: Aeromonas spp. are halophilic, Gram-negative bacilli. They are widely distributed in the soil and aquatic environment and have been associated with various extraintestinal infections, such as skin and soft-...
Evaluation of Analgesic and Anti-Inflammatory Activity of Ibuprofen-Pregabalin in Animal Models
ABSTRACT Introduction: Despite an enhanced recognition of the molecular mechanisms of nociception, existing analgesic drugs continue to remain restricted in terms of efficacy. Since all single analgesic drugs are not eff...
Filarial Pleural Effusion with Lymphoma: A Rare Association
ABSTRACT Filariasis is endemic in developing countries with highest prevalence in India. Microfilarias are infrequently reported during cytological examination of body cavity fluids. Its association with neoplasm is stil...
Evaluation of Maternal and Perinatal Outcomes of Induction in Borderline Oligohydramnios at Term
Introduction: Oligohydramnios is described as decreased amniotic fluid volume relative to gestational age. Semiquantitatively it is described using the Amniotic Fluid Index (AFI) which is calculated by adding the depth i...