PREVALENCE OF THALASSEMIA IN TRIBAL PATIENTS ATTENDING TERTIARY CARE HOSPITAL IN JHARKHAND
Journal Title: IJSR-International Journal Of Scientific Research - Year 2018, Vol 7, Issue 7
Abstract
Introduction: The inherited disorders of blood include hemoglobinopathies as one of the major public health problems in India. They cause a high degree of morbidity, moderate to severe hemolytic anemia among vulnerable segments of the society like infants and children, adolescent girls, pregnant women, etc. and several deaths in India. The cumulative gene frequency of the three most predominant abnormal hemoglobins, i.e. sickle hemoglobin, hemoglobin D and hemoglobin E has been found to be 5.35% in India. Prevalence of sickle gene is found to be 0-18% in North eastern India, 0-33.5% in Western India, 22.5-44.4% in Central India and 1-40% in Southern India. The sickling disorders- HbSS, HbSD, HbSE, HbS/ β- thalassemia and other compound heterozygous hemoglobinopathies are all clinically significant, as these combinations present with different manifestations and degrees of severity, making precise identification important. Automated cation-exchange High Performance Liquid Chromatography (HPLC) has emerged as an excellent screening tool for diagnosing these abnormal hemoglobins/ thalassemic states. Ÿ Aims and Objective: To determine the prevalence of different types of thalassemias and its distribution in tribal population attending the Pathology Department of RIMS Ranchi. Ÿ To correlate clinical and hematological features of thalassemias. Material and Methods: The present study entitled “Prevalence of Thalassemia in Tribal patients using High Performance Liquid Chromatography” was carried out in the Department of Pathology, Rajendra institute of Medical Sciences, Ranchi, for a period of one year (Jan 2015-Dec2015). The study was approved by Institutional Ethics Committee, Rajendra Institute of Medical Sciences. Conclusion: Out of 100 patients diagnosed with thalassemia using HPLC, 28 cases belonged to the Tribal population . In the present study the prevalence of β thalassemia trait in Tribals in Jharkhand was found to be 11%. β Thalassemia major in Tribals in Jharkhand was found to be 7%. Sickle β Thalassemia in Tribals in Jharkhand was found to be 10%. No cases of HbEβ Thalassemia in Tribals were found in Jharkhand during this period. The definite identification of disorders of hemoglobin synthesis can be achieved only by DNA analysis, but, in the Indian scenario, family studies on HPLC might be useful as there is paucity of funds, and facilities for DNA analysis are not readily available. Family study is an equally efficacious and cost effective tool. This highlights the role of premarital counseling.
Authors and Affiliations
Dr. Deepali Tirkey, Dr. Sunil Kumar Mahto
Keywords
Related Articles
- EP ID EP507506
- DOI -
- Views 39
- Downloads 0
INFLUENCE OF MUSIC THERAPY ON ANXIETY, PAIN PERCEPTION, HEART RATE AND BLOOD PRESSURE OF PATIENTS UNDERGOING ENDODONTIC TREATMENT – A RANDOMIZED CONTROL TRIAL
Background: Dental anxiety is a significant and challenging problem in patients seeking dental treatment. During any dental procedure patients often experience severe pre-operative and intra-operative anxiety which makes...
ABNORMAL UTERINE BLEEDING: CLINICOHISTOPATHOLOGICAL SPECTRUM AND CORRELATION
Background: Abnormal Uterine Bleeding (AUB) is considered one of the most common and challenging problems presenting to the gynecologists and accounts for as many as one third of all outpatients. Material and Methods: A...
THORACO-ACROMIAL ARTERY : A CADAVERIC STUDY OF ITS PEDICLE AND BRANCHES
Background of study- A detailed knowledge of variations in the origin and branching pattern of Thoraco-acromial artery(TAA) is important during various reconstructive and microvascular surgeries. Materials and methods- H...
CYTOMORPHOLOGICAL STUDY OF LYMPHADENOPATHY ON FINE NEEDLE ASPIRATION CYTOLOGY IN A TERTIARY CARE HOSPITAL OF WESTERN MAHARASHTRA
Introduction: Lymph nodes are the most widely distributed and easily accessible component of lymphoid tissue. A large spectrum of diseases including reactive processes,infections, lymphomas and metastatic tumors can caus...
CATHETER ASSOCIATED URINARY TRACT INFECTION IN INTENSIVE CARE UNIT IN A TERTIARY HOSPITAL IN CENTRAL INDIA
Urinary tract infections (UTIs) account for about 30%-40% of all hospital associated infections and are important since they increase mortality, morbidity, duration of hospital stay and health costs 1-3. The most importa...