PREVALENCE OF VITAMIN D DEFICIENCY IN HASHIMOTO’S THYROIDITIS AND ITS RELATION TO ANTI-THYROID PEROXIDASE ANTIBODIES
Journal Title: IJAR-Indian Journal of Applied Research - Year 2018, Vol 8, Issue 9
Abstract
Context: vitamin D deficiency has been considered a risk factor for several autoimmune diseases. Few studies examined prevalence of vitamin D deficiency in autoimmune thyroid disease and have produced conflicting results. Aims: To study the prevalence of vitamin D deficiency in Hashimoto’s thyroiditis (HT) and to assess the correlation between vitamin D and Antithyroid peroxidase antibodies (TPO-Ab). Settings and Design: This is a cross sectional case control study. Methods and Material:A total of 100 subjects, 50 HT patients and 50 healthy controls who were age and sex matched were included in the study. Serum 25(OH)D, fT4, TSH, TPO-Ab were measured. Subjects were categorized as vitamin D deficient(<12 ng/ml), vitamin D insufficient(12-20 ng/ml) and vitamin D sufficient (>20 ng/ml) based upon recent consensus guidelines. HT patients were categorized as euthyroid, sub clinical hypothyroid and overt hypothyroid based on fT4 and TSH. Results:The mean 25(OH)D level was 13.19±7.43ng/ml and 13.66±8.61ng/ml in HT patients and healthy controls respectively.Prevalence of vitamin D deficiency was 56% in HT and 50% in controls. Vitamin D insufficiency was observed in 20% of HT and 36% of healthy controls. There was no significant difference in 25(OH)D levels of overt hypothyroid, subclinical hypothyroid and euthyroid HT patients(p=0.23). Pearson correlation analysis showed no significant correlation between vitamin D and TPO-Ab,TSH and fT4. Conclusions: The prevalence of vitamin D deficiency in hashimoto’s thyroiditis and healthy controls was similar confirming high prevalence of vitamin D deficiency in general population. Vitamin D deficiency did not differ between euthyroid,sub clinical hypothyroid and overt hypothyroid patients of HT.There was no correlation between vitamin D and TPO-Ab.
Authors and Affiliations
Mounika Anitha CH, Vivekanand B, Mythili A, Jayanthy Ramesh, Subrahmanyam KAV
Keywords
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