Prevalence of Vitamin-D deficiency in Ulcerative Colitis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
INTRODUCTION: Ulcerative colitis is a chronic inflammatory disease of the colon of unclear etiology with an increasing incidence in India. Immunomodulatory effects of vitamin-D has been linked to autoimmune disease such as ulcerative colitis and deficiency of vitamin-D has been found to correlate with severity and activity of disease. In our study we evaluated the prevalence of vitamin-D deficiency in mild,moderate, and severe ulcerative colitis. AIM: To Study the prevalence of vitamin-D level and deficiency in Ulcerative colitis patient at our centre. METHODS: Retrospective data of70 Patients with Ulcerative colitis diagnosed by clinical, endoscopic and histopathologic evaluation from 2015-2017 at our centre were included in the study and they are classified into mild,moderate,severe by Truelove and Wittscriteria.Serum vitamin-D levels were measured in all patients and 70 healthy controls. Patients with mean age of 22-55 years and no comorbid illness such as Diabetes Mellitus,SystemicHypertension,Chronic kidney disease were included in the study.Vitamin-D levels were defined as Sufficient(>30ng/mL), Insufficient(20-30ng/mL), Deficient(<20ng/mL). RESULTS: 70 patients(male=43,female=27) with mean age of 40 years and average symptom duration of 6 months prior to our hospital visit were reassessed during follow up at our hospital. They were classified into mild UC group n=23(32.8%), moderate UC group n=31(44.28%) and severe UC group n=16(22.85%).Among study group 18(78.26%)patients in mild UC 26(83.87%)patients in moderate UC and 14(87.5% )patients in severe UC group were vitamin-D deficient. Among 70 healthy controls serum vitamin-D levels were deficient in 18(25.71%)patients and insufficient in 22(31.42%) patients. CONCLUSIONS: We conclude that immunomodulatory property of serum vitamin-D might be a contributory factor to disease activity of ulcerative colitis, however other factors such as infections, poor compliance to treatment and steroid resistance should also be considered.
Authors and Affiliations
Dr. S. B. Malipatil
Keywords
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- EP ID EP467564
- DOI 10.9790/0853-1802092526.
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