Prevention of Cardiac Myocyte Changes by Raloxifene, a Selective Estrogen Receptor Modulator (SERM) in Rat Model of Surgically Induced Estrogen Depleted State
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 9
Abstract
Background: Cardiac failure, Cardiovascular diseases (CVD) including coronary artery, cerebrovascular and peripheral vascular disease are the leading causes of morbidity and mortality in both men and women, although female sex has long considered to be a “protective factor†against CVD. This study evaluated the effect of Selective estrogen receptor modulator (SERM) Raloxifene (RAL) therapy on endo-myocardium for therapeutic effectiveness in estrogen-depleted states induced by ovariectomy (OVX). Methods: We divided the rats into four groups: (I) Sham operated (II) ovariectomized controls without any treatment, (III) ovariectomized rats treated with vehicle sesame oil (IV) ovariectomized rats treated with raloxifene 1 mg/kg, s.c. daily for 60 days. Rats were sacrifced by transcardial perfusion. Different chambers of the heart sections were analyzed by image analysis software after hematoxylin and eosin staining. Results: This study reported that an increase in heart weight, cardiac wall thickness and myocytes diameter in response to estrogen depletion that can be effectively reversed by raloxifene treatment. Conclusion: This research revealed that the raloxifene treatment is the novel strategy to alleviate the post-menopausal problems and prevent the heart failure due to cardiac hypertrophy without the adverse effect of estrogen. This original article can give an idea to develop a cardioselective SERM`s which can be a used in both genders. The further studies are needed to fnd the molecular mechanisms of raloxifene over the hypo estrogenic cardiac myocytes.
Authors and Affiliations
Suresh Selvaraj| Department of Anatomy, Faculty of Medicine, Quest International University Perak, Ipoh, Malaysia, Ritu Sehgal| Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India, Corresponding e-mail: drsureshsmd@gmail.com, Raj D Mehra| Department of Anatomy, Hamdard Institute of Medical Sciences and Research, New Delhi, India, Pushpa Dhar| Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India, Gayathri Rajamanickam| Faculty of Pharmacy, Quest International University Perak, Ipoh, Malaysia
Keywords
Related Articles
- EP ID EP12456
- DOI -
- Views 337
- Downloads 14
The relationship between Exercise and premenstrual syndrome
Premenstrual syndrome (PMS) starts during puberty years and it continues to the menopausal period. PMS manifests itself during every monthly luteal stage in the form of a complex of somatic, psychological and behavioral...
ETIOLOGY AND TREATMENT OUTCOME OF PEDESTRIANS WITH TRAUMATIC BRAIN INJURIES FROM ROAD TRAFFIC CRASHES
Context: That unconscious man on the road being taken into the ambulance was knocked down by a vehicle. The energy he absorbed from the impact was proportional to the weight of the vehicle with its occupants, and to t...
The study of Job Stress and Tension Management among Oncology Nurses of Ahvaz Hospitals in 2015
Nursing care for cancer patients is stressful for nurses and to maintain the quality of care they should be able to manage these tensions. Therefore, the aim of current study was to determine the level of job stress and...
PANCREATIC LIPASE AND α-AMYLASE INHIBITORY POTENTIAL OF MANGOSTEEN (GARCINIA MANGOSTANA LINN.) PERICARP EXTRACT
Background: Obesity is a disorder of lipid metabolism and the enzyme involved in this process could be selectively targeted to develop anti obesity drugs. Inhibition of digestive enzymes is one of the most widely studi...
CONGENITAL GIANT MELANOCYTIC NEVI – TIP OF THE ICEBERG
Congenital Giant Melanocytic Nevus (CGMN), pigmented lesion present since birth, occurs in 1 % of infants worldwide. Fifteen percent of CGMN are localized in the head and neck region and it can also have a bathing trunk...