PREVENTION OF PARACETAMOL TOXICITY IN BROILER CHICKS WITH A HERBAL MIXTURE
Journal Title: Indian Journal of Scientific Research - Year 2017, Vol 8, Issue 1
Abstract
Fourteen days old broiler chicks were pretreated orally with a mixture of six herbal products Terminalia chebula , Glycyrrhiza glabra, Curcuma longa, Triphala, Asparagus racemosus and Ocimum sanctum at three doses levels (group IV, V and VI) for seven days and on 7th day all chicks received single sublethal dose of acetaminophen (paracetamol) via i.m injection at (LD5). Controls (Gr-I) received only distilled water and one injection of vehicle. Only drug treated chicks were also maintained (Gr-II). One group (Gr-III) received only distilled water and received single i.m. injection of paracetamol at LD5. Chicks were sacrificed on 9th day to obtain blood and tissues for hematological, histological and biochemical observations. Paracetamol declined hemoglobin content, damaged RBC, caused anemia and increased serum levels of bilirubin, GOT (glutamic-oxaloacetic transaminase), GPT (glutamic-pyruvic transaminase), alkaline phosphatase, urea and creatinine indicating hepatorenal tissue injury. Early degenerative changes could be detected in liver, kidney, spleen, left ventricular wall, lungs and proventriculus. Pretreatment with lowest dose of herbal mixture remained ineffective but medium and highest doses could fully prevented toxic effects of paracetamol. In-vitro of testing herbal mixture is found to possess antioxidative activity. Pretreatment with highest dose of herbal mixture enhanced hepatic GSH content than control (Gr-II) and even maintained normal (control) like levels following paracetamol challenge in all groups. Probable protective role played by herbal mixture against paracetamol toxicity based on its antioxidant principles, minerals and vitamins is discussed.
Authors and Affiliations
Savita Marmat
Keywords
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