PREVENTION OF PEPTIC ULCERS BY CURCUMIN IN CHEMICALLY INDUCED OSTEOARTHRITIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 4
Abstract
Objective: The present study was carried out to investigate the role of curcumin in osteoarthritis when it is used as an adjuvant to diclofenac sodium.Methods: Osteoarthritis (OA) was induced by administering nalidixic acid 400 mg/kg. Animals (Female rats) were divided into 5 groups each containing 6 animals. Group I was considered as control, group II in which the animals were induced with osteoarthritis with nalidixic acid and were given no treatment. Group III in which osteoarthritis induced animals were treated with diclofenac sodium by the oral route. Group IV osteoarthritis induced animals were treated with the combination of diclofenac sodium and curcumin and group V animals were pre-treated with curcumin and then induced with osteoarthritis. Parameters like ulcer area, ulcer index, free acidity, total acidity, the volume of gastric juice were estimated. Histopathological studies were also carried out.Results: The data of our study shows that nalidixic acid has not shown much effect on the gastric parameters in group II animals. The ulcer index, free acidity, total acidity and gastric juice volume were increased significantly (p<0.001) in group III and decreased in group IV animals (p<0.05) when compared to group I control animals. Group V animals pretreated with curcumin have shown fewer incidences of gastric ulcers and other ulcerative parameters non significantly. Histopathology also suggests a low incidence of ulcers in group IV and group V.Conclusion: It demonstrates that curcumin when used along with the conventional NSAIDs as an adjuvant therapy, has a role in treating osteoarthritis effectively.
Authors and Affiliations
Nasreen Sulthana, Vijaya K.
Keywords
Related Articles
- EP ID EP567518
- DOI 10.22159/ijpps.2018v10i4.24327
- Views 68
- Downloads 0
EFFECT OF AQUEOUS EXTRACT OF AZOLLA FILICULOIDES IN GASTRIC MUCOSA OF ULCERATED RATS
Objective: To investigate the anti ulcer effect of aqueous extract of Azolla  filiculoides (AF) in experimentally induced gastric ulceration in male Wistar rats.Methods: Twenty four rats were divided into four groups of...
A COMPARATIVE STUDY ON THE IN-VITRO ANTIMICROBIAL ACTIVITY OF THE ROOTS OF FOUR THOTTEA SPECIES
Objective: The main objective of the present study was to investigate the antimicrobial activity of the methanol extract of the roots of four Thottea species.Methods: The root extracts of four Thottea species were subjec...
CD4 T-HELPER CELL COUNT IS AN ALTERNATIVE PROMISING MARKER FOR DOSING CYCLOSPORINE IN KIDNEY TRANSPLANT PATIENT
Objective: The study was aimed to find out the correlation between cyclosporine blood concentrations and (Clusters of Differentiation 4) CD4 T-helper cell count (percentage) in order to use the latter parameter as an alt...
MITIGATING ROLE OF ZINC AND IRON AGAINST CADMIUM INDUCED TOXICITY IN LIVER AND KIDNEY OF MALE ALBINO RAT: A STUDY WITH REFERENCE TO METALLOTHIONEIN QUANTIFICATION
Objective: The present study is carried out to know the mitigating role of zinc (Zn) and / or iron (Fe) supplementation on cadmium (Cd) induced toxicity in rats with special reference to metallothionein (MT) protein.Meth...
A SINGLE CASE REPORT ON HYPONATREMIA SEIZURE INDUCED BY ACETYLCHOLINESTERASE INHIBITORS
Donepezil and memantine are the acetylcholinesterase inhibitors most commonly used in clinical practice for the management of mild-moderate dementia in Alzheimer’s disease. Electrolyte abnormalities associated with the...