Preventive and therapeutic effects of berberine on liver diseases and its mechanism
Journal Title: Journal of Clinical Hepatology - Year 2024, Vol 40, Issue 11
Abstract
Berberine is an antipyretic and detoxicating drug commonly used in clinical practice， and it is currently used for the routine treatment of gastrointestinal diseases such as bacterial gastroenteritis and diarrhea. However， several recent studies have shown that berberine can exert a therapeutic effect on the diseases such as autoimmune hepatitis， viral hepatitis， nonalcoholic fatty liver disease， and liver cancer by regulating the AMPK and TGF-β pathways and altering the composition of intestinal flora. This provides new drugs for the treatment of these diseases， expands the potential indications of berberine， and provides clues for the follow-up research and development of similar drugs. This article summarizes the therapeutic effect and mechanism of berberine on various liver diseases， in order to provide a reference for effective clinical application.
Authors and Affiliations
Huili WANG, Wenhao QIN, Dangdang YANG, Yaqian NING, Shan LIN, Songlin DAI, Bing HU
Keywords
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- EP ID EP753495
- DOI 10.12449/JCH241130
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