Preventive Effects of Enicostemma littorale Blume Extract against Dexamethasone Induced Insulin Resistance in Wistar Rats
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2019, Vol 8, Issue 3
Abstract
Background: Insulin resistance is a pathological condition in which physiological levels of insulin produce only subnormal biological responses. In such instances, â cells of the pancreas produce more insulin but the cells in other body tissues are resistant to insulin leading to hyperinsulinemia, and subsequent hyperglycemia further results in metabolic syndrome. Aim and Objectives: This study was aimed to evaluate the hydro-alcoholic extract of Enicostemma littorale (ELE) in preventing dexamethasone 8mg/kg induced insulin resistance. Materials and Methods: Thirty-six male Wistar rats were categorized into Group I plain control that received distilled water, Group II dexa control that received dexamethasone 8mg/kg. Group III and Group IV received dexamethasone 8 mg/kg along with Metformin 500 mg/kg and 1g/kg respectively. Group V and VI received dexamethasone along with ELE 2.5 g/kg and 3.5 g/kg respectively. At the end, the fasting and repeated blood samples were collected at 30, 60 and 120 min for the estimation of post Intraperitoneal Glucose Tolerance Test (IPGTT), serum glucose and insulin. Data were utilized for the assessment of the homeostasis model of assessment for insulin resistance and sensitivity, Gutt, Matsuda, fasting glucose to insulin ratio and disposition indices. Results: All insulin sensitivity indices were worsened in dexa control group as compared to plain control (P<0.05). ELE 3.5 g/kg significantly lowered fasting glucose and insulin compared to metformin 1 g/kg (P<0.05), and significantly prevented the fall of insulin sensitivity indices compared to dexa control group (P<0.05). Glycosuria and ketonuria were also absent in ELE 3.5 g/kg group. Conclusion: ELE 3.5 g/kg showed efficacy in preventing insulin resistance evidenced by improved insulin sensitivity indices comparable with that of metformin 1 mg/kg.
Authors and Affiliations
Chinta Rajasekhar, I. M. Nagendranayak, Nagarajukokila . , JettiRaghu .
Keywords
Related Articles
- EP ID EP629999
- DOI -
- Views 97
- Downloads 0
The Editorial Policy on Conflict of Interest- A Major Issue for the Indian Medical Journals
Pulmonary Talco-silicosis in a Balloon Making Industry Worker
We report a case of a thirty eight year old lady, working in balloon making industry. She was referred to us in view of incidental chest X-ray changes found during preoperative pulmonary evaluation. She was asymptomatic...
Toxoplasma Antibody Titers in Mania: A Cross Sectional Study
Background: Recent studies have found a role of infectious agents, especially Toxoplasma gondii, in pathology of bipolar disorder - mania. Aim and Objectives: This study was conducted with the aim to find the prevalence...
A Case Report of Munchausen Syndrome by Proxy Presenting as Acquired Symptomatic West Syndrome
Munchausen Syndrome By Proxy (MSBP) is an extremely complicated diagnosis because of the difficulty in finding the incriminating evidence of its existence and because of the ethical issue it raises for caregivers. It...
An Unusual Cause of Elbow Pain – A Case Report
Giant cell tumours are common bone tumours usually benign which arise at the metaphysis and extend towards the epiphysis of bone. A case of giant cell tumour in the distal humerus which is a rare site is presented he...