Preventive Role of Fish oil (Omega-3 Fatty Acids ) Against HCl Induced Oxidative Stress in Rat Gastric Mucosa
Journal Title: International Journal of Medical and Health Sciences - Year 2012, Vol 1, Issue 3
Abstract
Fish oil contains more amount of Omega-3-fatty acids and have more biological uses than alphalinolenic acid. The goal of this study was to evaluate the antioxidant and gastric mucosal protective activity of fish oil in HCl-ethanol induced oxidative stress in gastric mucosa. In this study rats was divided into 5 groups. 5% and 10% v/w of fish oil used as test-I and test-II, Ranitidine (30/kg/orally) used as a standard. All the groups were administered normal diet for 30 days . On the 31st day 1.5 ml of HCl was administered orally to induce oxidative stress in gastric mucosa. The stomach was removed and subjected to estimation of antioxidant levels in homogenate and a part of stomach was used for histopathology. In this study significant increased lipid peroxidation and decreased glutathione, glutathione peroxidase, catalase and superoxide dismutase in the HCl treated group compared to Ranitidine and Fish oil administered groups was observed. The HCl administered rat stomach histopathology observations showed extensive injury to the epithelial layer compared with other groups. In conclusion administration or dietary supplementation of fish oil prevent the gastric mucosal damage induced by various oxidizing agents.
Authors and Affiliations
Divakar. V,Sylvia Shanthakumar, Devika. T, Sarath Babu. K
Keywords
Related Articles
- EP ID EP39672
- DOI -
- Views 297
- Downloads 0
Disseminated Cryptococcosis In An Immunocompetent Patient In Northeast India Caused By Serotype B -A Case Report
Disseminated cryptococcosis is not common in immunocompetent persons. Here we report a case of disseminated cryptococcosis in an immunocompetent individual caused by Serotype B. Detailed case history with informed cons...
Is Socioeconomic Status an Important Predictor of Alcohol use?: A cross-sectional study in an urban slum of Meerut
Background: Of all addictions like opiods, cannabinoids, sedatives, cocain, caffeine,hallucinogens, tobacco and other psychoactive drugs, it is the addiction to alcohol that remains the most important. Perhaps, this is...
Prevalence of Anemia Among Female Undergraduate Students of Government Medical College Kottayam, Kerala
Background: Anemia is a problem among young adult females. The present study was planned to estimate the prevalence and selected determinants of anemia among female undergraduates of Government Medical College Kottayam....
Sonographic Evaluation of Cervical Lymphadenopathy in Differentiation of Benign From Malignant Neck Nodes
Background: Nodes are the common site for Inflammatory, Infective (Viral, Bacterial, and Protozoan) and neoplastic involvement. Cervical lymph nodes, which have the advantage of being located superficially, can be studi...
Hand washing Knowledge and Practice among mothers of under-five children in coastal Karnataka, India – A cross-sectional study
Washing one’s hands with soap following critical moments like after toilet use, after cleaning a child’s bottom and before handling food is an important barrier to the transmission of pathogens causing diarrhea and acut...