Preventive Role of Fish oil (Omega-3 Fatty Acids ) Against HCl Induced Oxidative Stress in Rat Gastric Mucosa
Journal Title: International Journal of Medical and Health Sciences - Year 2012, Vol 1, Issue 3
Abstract
Fish oil contains more amount of Omega-3-fatty acids and have more biological uses than alphalinolenic acid. The goal of this study was to evaluate the antioxidant and gastric mucosal protective activity of fish oil in HCl-ethanol induced oxidative stress in gastric mucosa. In this study rats was divided into 5 groups. 5% and 10% v/w of fish oil used as test-I and test-II, Ranitidine (30/kg/orally) used as a standard. All the groups were administered normal diet for 30 days . On the 31st day 1.5 ml of HCl was administered orally to induce oxidative stress in gastric mucosa. The stomach was removed and subjected to estimation of antioxidant levels in homogenate and a part of stomach was used for histopathology. In this study significant increased lipid peroxidation and decreased glutathione, glutathione peroxidase, catalase and superoxide dismutase in the HCl treated group compared to Ranitidine and Fish oil administered groups was observed. The HCl administered rat stomach histopathology observations showed extensive injury to the epithelial layer compared with other groups. In conclusion administration or dietary supplementation of fish oil prevent the gastric mucosal damage induced by various oxidizing agents.
Authors and Affiliations
Divakar. V,Sylvia Shanthakumar, Devika. T, Sarath Babu. K
Keywords
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