Primary Endometrial Squamous Cell Carcinoma In Situ Report of a rare disease
Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 4
Abstract
Squamous cell carcinoma (SCC) of the endometrium, whether primary or secondary to cervical cancer, is a rare entity. Primary endometrial squamous cell carcinoma in situ is even more uncommon; it usually occurs in postmenopausal women and has a strong association with pyometra. We report a 60-year-old multiparous postmenopausal woman who presented to the Hakeem Abdul Hameed Centenary Hospital, New Delhi, India, in May 2014 with a lower abdominal swelling corresponding in size to a pregnancy of 26 gestational weeks and vaginal discharge of one year’s duration. A total abdominal hysterectomy with a bilateral salpingooophorectomy was performed, which revealed an enlarged uterus with pyometra. Histopathology showed that the entire endometrial lining had been replaced with malignant squamous cells without invasion of the myometrium. Immunohistochemistry revealed that the tumour cells were positive for p63 with a high Ki-67 labelling index. No adjuvant therapy was required and the patient was disease-free at a seven-month follow-up.
Authors and Affiliations
Sujata Jetley| Departments of Pathology, Hamdard Institute of Medical Sciences & Research, New Delhi, India, Zeeba S. Jairajpuri| Departments of Pathology, Hamdard Institute of Medical Sciences & Research, New Delhi, India, Mohammad J. Hassan| Departments of Pathology, Hamdard Institute of Medical Sciences & Research, New Delhi, India, Garima Madaan| Departments of Pathology, Hamdard Institute of Medical Sciences & Research, New Delhi, India, Reena Jain| Departments of Obstetrics & Gynaecology, Hamdard Institute of Medical Sciences & Research, New Delhi, India
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