Primary hepatic neuroendocrine tumour requiring live donor liver transplantation: case report and concise review
Journal Title: Annals of Hepatology - Year 2012, Vol 11, Issue 5
Abstract
Primary hepatic neuroendocrine tumours are rare tumours effecting relatively young patients. As metasta-tic neuroendocrine tumours to the liver are much more common, extensive investigations are crucial toexclude a primary tumour elsewhere. We report a case of a 27 year old woman who presented with fati-gue, increased abdominal girth and feeling of early satiety and bloating. Extensive work up failed to showtumour at another primary site. Hepatic artery embolization showed no effect, so the patient underwenttotal hepatectomy and live-donor liver transplant. Grossly the tumour measured 27 cm. Microscopic exami-nation showed bland, monomorphic cells growing in tubuloglandular and trabecular growth patterns. Cellswere positive for neuroendocrine (synaptophysin, chromogranin, CD56) and epithelial markers (MOC31,CK7, CK19). Cytoplasmic dense neurosecretory vesicles were seen on ultrastructural examination. Based onthe Ki-67 rate, mitotic count, lack of marked nuclear atypia and absence of necrosis, a diagnosis of primaryneuroendocrine grade 2 was conferred.
Authors and Affiliations
Ananta Gurung, Eric Yoshida, Charles Scudamore, Almoutaz Hashim, Siegfried Erb, Douglas Webber
Keywords
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