Primary hypothyroidism associated with myopathy
Journal Title: Journal of Neurological Sciences-Turkish - Year 2005, Vol 22, Issue 1
Abstract
Deficiency of thyroid hormone leads to hypothyroidism and low free thyroxine and tri-iodothyronine (Free T4, T3) levels and increased thyroid stimulating hormone (TSH) are seen in primary hypothyroidism. Clinical features characterised by generalized weakness, lethargy, sleepiness and fatigue, slow speech, slow thought, cold intolerance, bradycardia, menstrual irregularity, depression, constipation, and weight gain. In addition to, neuromuscular findings may be seen such as myopathy and sensory-motor axonal neuropathy. The muscle biopsy shows atrophy and loss of the type II fibers, increased internal muscle cell nuclei. A 28-year-old male who has fatigue, cold intolerance, mental slowing, muscle cramping, cramps, weakness was accepted our department. Free thyroxine and tri-iodothyronine levels were 0.27 ng/dl and 0.10 pg/ml respectively. TSH level was 135.52 mIU/L. Creatine kinase, SGOT, and SGPT levels were high ( 4869 U/L , 156 U/L, 60 U/L). Based on history, physical and neurological examinations, histopathological and laboratuary analyses, he was diagnosed as as primer hypothyroidism associated with myopathy, and was given Levothyroxine.
Authors and Affiliations
A KOC, Ali OZEREN, Suzan ZORLUDEMIR, Gamze ALMAK
Keywords
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