Primary Pulmonary Epithelial- Myoepithelial Tumour - Report of an Aggressive Clinical Case
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 10
Abstract
Primary epithelial-myoepithelial tumor is usually a salivary gland neoplasm and extremely rare in the respiratory tract. These tumors are thought to arise from tracheo-bronchial submucosal glands. They usually present as early lesions due to the endobronchial location and have a benign course after surgical resection. In literature about twenty five cases have been reported so far and almost all of them had small tumors with a mean size of 2.5 cm with good prognosis after radical resection. We report a case with large unresectable primary pulmonary epithelial-myoepithelial tumour. The patient was a fifty eight year old gentleman who presented with a three week history of cough, chest pain, and breathlessness. CT scan of thorax showed a large heterogeneous mass lesion occupying upper right hemithorax infiltrating the great vessels. Trucut biopsy showed a neoplasm composed of cells arranged in diffuse sheets and glandular pattern with interspersed hyalinised material. Immunohistochemistry showed epithelial cells strongly positive for cytokeratin and myoepithelial cells positive for p63. There was myoepithelial cell predominance and MIB 1 index was 7/10 HPF. Our case had an aggressive clinical course with poor response to chemotherapy and expired after nine months of diagnosis due to progressive disease. None of the reported cases had an extensive tumour with aggressive clinical behaviour as in our case.
Authors and Affiliations
Dr Geethi M H
Keywords
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