Priming of neutrophil respiratory burst by tumor necrosis factor-α
Journal Title: Journal of Analytical Bio-Science - Year 2012, Vol 35, Issue 4
Abstract
It is known that the phenomenon called priming occurs in the O2- production by neutrophils. A certain stimulating factor leads to the priming of neutrophils, and another stimulating factor enhances the production of O2- significantly. This phenomenon is considered to occur universally inside the living body at the time of inflammation. It functions to strengthen the biological defense mechanism by neutrophils. On the other hand, it has been reported that priming activates neutrophils and causes cellular disorder. However, the signaling of priming has not been clarified. In this study, the author discussed the signaling of priming by TNF-α. In the signaling due to fMLP stimulation after priming, it was observed that the p38MAPK and Erk1/2 systems are activated via tyrosine kinase and then p47phox is phosphorylated. It was indicated that this signaling activates NADPH oxidase and enhances the production of O2-.
Authors and Affiliations
Yasuhiko Ohota
Keywords
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