PROCESS DEVELOPMENT FOR SYNTHESIZING CEFETAMET SODIUM
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 1
Abstract
The research work relates to an improved and cost effective process for the industrial manufacture of Cefetamet Sodium. More specifically it relates to preparation of products of good quality with high yield and the by products are removed and the same can be recycled using simple industrial and viable method. It can be possible with by using intermediate MAEM to synthesize Cefetamet Sodium. The drug is registered in USP and belongs to 3rd generation drug. There are many patents which gives the procedure of Synthesis of Cefetamet Sodium. These synthesis procedures have taken as standard procedure for pursuing the project work. At present, MAEM is highly used intermediate to synthesis cephalosporin antibiotics. In this project work modification has done for synthesizing of cephalosporin antibiotics by utilizing MAEM as intermediate and other chemicals like different Lewis acid, and solvent as alternate of intermediate, chemicals and solvents which are given in patents to synthesize cephalosporin antibiotics .Resulting yield has improved via making small time synthesis reaction .This is helpful for the commercial purpose. Cephalosporins are the highly used Broad spectrum antibiotics; belong to β-lactam class. The bactericidal action of beta lactam antibiotics is directly attributable to their ability to react with PBP's. The Reaction monitoring was done by HPLC and identification of final product was done by MASS, I.R, NMR and then comparing with the well known literature. Recovery of the side product and byproduct (mercaptobenzothiazole) were achieved to allow a greener process and utilizes for synthesis of other familiar drugs. Keywords: Cefetamet Sodium, IR, NMR, TLC, HPLC, Mercaptobenzothiazole
Authors and Affiliations
Mohammed Khalid Ali
Keywords
Related Articles
- EP ID EP416748
- DOI -
- Views 211
- Downloads 0
Nanotheranostic: Nanomedicine and future development
Nanotechnology holds a productive potential about to happen explored as a multifunctional word of light at end of tunnel for a wide alps of biological and engineering applications a cleanly known as molecular sensors for...
Pre-formulation studies and Evaluation parameters of Bioadhesive Gel Incorporated Metronidazole Loaded Microspheres
Metronidazole is an antiprotozoal and antibacterial medication used mainly in the treatment of anaerobic bacteria. The preformulation studies were carried out in terms of tests for identification (physical appearance, me...
ROLE OF YASTHIMADHU CHURNA IN THE MANAGEMENT OF HYPERACIDITY W.S.R TO AMLAPITTA: A REVIEW STUDY
Hyperacidity is a disease of gastrointestinal tract due to abnormal secretion of gastric and pancreatic enzymes. In medical science it is described as Acid Peptic Disorder (APD). In Ayurveda it is described as Amlapitta....
DRUG UTILIZATION REVIEW IN PEDIATRICS AT THE TERTIARY CARE TEACHING HOSPITAL
To understand the prescribing patterns of various classes of drugs in Pediatrics and to identify the barriers associated with rational prescribing of pediatric drugs. Methodology: A Prospective-observational study was ca...
COMPARISON OF THE THERAPEUTIC ACTIONS OF TAURINE, METHYLSULFONYLMETHANE AND SILYMARIN AGAINST ACETAMINOPHEN-INDUCED NEURO- AND HEPATO-TOXICITY IN ADULT MALE ALBINO RATS.
To evaluate the neuro- and hepato-curative effects of taurine (TAU) and methylsulfonylmethane (MSM) in acetaminophen- induced neuro- and hepato- toxicity in adult male albino rats. Silymarin (SLN) was used as reference d...