Production of Free Radicals by Mitochondria: A Biochemistry Approach
Journal Title: International Journal of Science and Innovative Research - Year 2020, Vol 1, Issue 01
Abstract
The production of superoxide by mitochondria strongly depends on the mitochondrial respiratory chain. It is believed that the acetylation of cytochrome c prevents its reoxidation by mitochondrial cytochrome oxidase and direct reduction by NADH or succinate dependent cytochrome c reductase. It is believed that ubiquinone can be one of the major producers of superoxide, because the depletion of endogenous ubiquinone resulted in the formation of diminishing hydrogen peroxide.
Authors and Affiliations
Usman Garba Kurmi1*, Fatima Abubakar2, Ruqayya Ali Uthman3, Isah Adamu Baushe5, Hadiza Abubakar Balkore1, Khadija Muhammad4, Prosper Obed Chukwuemeka6
Keywords
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