PRODUCTION OF LOVASTATIN FROM FUNGAL SOURCES AND ITS MEDICAL APPLICATIONS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Lovastatin and other natural as well as synthetic statins are considered as wonder drugs for treatment of hypercholesterolemia. Statins are produced by many fungal sources mainly from Aspergillus terreus on industrial scale. Lovastatin lowers blood cholesterol levels dramatically by inhibition of hydroxymethyl glutaryl-coenzyme A (HMG-CoA) reductase which is enzyme required for catalyzing rate limiting step for de novo cholesterol synthesis. This competitive inhibition is due to structural similarity between HMG-CoA and acid form of lovastatin. Lovastatin possess a hydroxyl hexahydro naphthalene ring which is polyketide chain to which different side chains are attached. Lovastatin synthesis starts from linkage of acetate units in head to tail fashion establishing main polyketide chain. First intermediate formed during synthesis is monacolin L which is then turned into monacolin J by hydroxylation which in turn gets converted into lovastatin. Molecular studies revealed that genetic cluster involved in biosynthetic pathway includes genes LovB, LovC,LovA,LovD,LovF and Lov H. Industrially lovastatin is produced by liquid submerged fermentation but now a day’s use of solid state fermentation is gaining importance. Lovastatin serves as drug of choice for cardiovascular diseases like peripheral vascular disease, atherosclerotic plaque, peripheral arterial disease, cerebro vascular disease, sepsis and ischemic heart disease. It also shows many other biological effects beyond just lowering cholesterol level that include its effects on bone maturation, renal disorders treatment, anticancer and metabolic syndrome.
Authors and Affiliations
Dr. Sikander Ali
Keywords
Related Articles
- EP ID EP630381
- DOI -
- Views 196
- Downloads 0
EVALUATION OF ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF BARK & LEAF EXTRACTS OF BAUHINIA ACUMINATA
The prime interest of the current study was to investigate the antioxidant & antimicrobial activity from the ethanolic extracts ofbark and leaf of the herb Bauhinia acuminata.Three antioxidant methods were followed to in...
THE MTOR INHIBITOR RAPAMYCIN INDUCES CTGF AND TIMP-1 EXPRESSION IN RAT KIDNEY: IMPLICATION OF TGF-/SMAD SIGNALING CASCADE
The mTOR-inhibitor rapamycin is a potent drug used as immunosuppressive agent. It is usually used either alone or in combination with calcineurin inhibitors. Despite its beneficial role in organ transplantation rapamycin...
EXFOLIATIVE DERMATITIS SECONDARY TO THYMOMA: A RARE ASSOCIATION
Exfoliative dermatitis (ED), also referred to as erythroderma, is a scaling erythematous dermatitis involving 90% or more of the cutaneous surface. In ED the rate of epidermal turnover, the number of germinative cells, a...
MODERN LIFESTYLE A RISK AND PREDISPOSING FACTOR OF MUSCULOSKELETAL DISORDERS
Ayurveda has a holistic approach towards lifestyle disorders and there are many diseases which are caused due to management of lifestyle. The burden of these lifestyle disorders is increasing day by day in the society. T...
THE POSSIBILITIES OF MOLECULAR-BIOLOGICAL MARKERS IN SUPPRODUCTIVE IMMUNOTHERAPY IN PATIENTS WITH ONCINE-INTAL DISEASES
The aim of the study was to study the expression of molecular biological tumor markers in patients with cervical cancer and ovarian cancer, and their effect on the course of accompanying immunotherapy. It was shown that...