PROFESSOR BORYS ZIM ENKOVSKY’S SCIENTIFIC SCHOOL IN THE LIGHT OF M ODERN EUROPEAN SCIENTIFIC TRENDS: YESTERDAY, TODAY, TOMORROW
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2015, Vol 43, Issue 2
Abstract
Scientific school investigating chemistry and pharmacological profile of azolidinones, thiazanes and related heterocycles had been developed and successfully led by prof. B. Zimenkovsky at the department o f pharmaceutical, organic and bioorganic chemistry of Danylo Halytsky Lviv National Medical University. This scientific project involving several generations o f chemists, biologists, pharmacologists and drug technologists has more than 50 years traditions and its development has been always in the scope o f European and global trends o f pharmaceutical and medical science. The founder of scientific school of thiazolidone’s and 1,3-thiazane’s chemistry was prof. M.M. Turkevych. Continuing the work o f his teacher, prof. B. Zimenkovsky has not only saved the traditions but also had achieved significant progress and a new level in the field o f directed synthesis o f sulfur and nitrogen containing hetrocycles as potential drugs. Given the revolutionary changes in the process o f novel drugs creation the scientific research strategy carried out under the supervision o f prof. Zimenkovsky B.S., since 2000, has undergone some rethinking in the context o f introduction o f new approaches to the biologically active compounds directed synthesis. Thus, at the present stage the ideology of scientific school is based on three fundamental vectors: organic synthesis, pharmaceutical research and rational approaches to "drug-like ” molecules design (virtual screening, QSAR-analysis, molecular docking, mathematical modeling techniques). Synthetic studies of 4-azolidinones and related heterocyclic systems allowed obtaining the library that includes more than 6000 compounds. To date there were carried out more than 2000 biological activity assays that allowed to identify 148 compounds with anticancer activity, 40 compounds showing significant antituberculosis activity, 25 compounds showing antitrypanosomal activity and 30 compounds with high antiviral activity. During last 5 years the disciples of Zimenkovsky’s scientific school have published more than 50 articles in a peer-reviewed journals with impact factors, having achieved total impact factor indicator o f 90,9. The level o f scientific school’s citations demonstrates significant interest showed by the academic community in the results of its research. So, in 2015 according to science metric database SciVerse Scopus articles of prof. Zimenkovsky B.S. and his disciples were cited more than 1,200 times, and the Hirsh index is 18.The key task of scientific school is the creation and implementation of innovative medicine with an original mechanism o f action for enhanced pre-clinical and clinical studies.
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Roman LESYK
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