Profile of Mineral Bone Disease in Chronic Kidney Disease Patients in a Tertiary Care Center
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 5
Abstract
Introduction: Chronic kidney disease related-mineral bone disorder (CKD-MBD) has been poorly studied in pre-dialysis Indian CKD patients. Aim: The aim of the study is to study the clinical, mineral abnormalities in Stage 3-5 CKD patients. Materials and Methods: A hospital-based cross-sectional survey including, demographic profile, history of CKD-MBD symptoms, measurement of serum calcium, intact parathyroid hormone (iPTH), magnesium, phosphorus, and Vitamin D bone alkaline phosphatase (BAP) in Stage 3-5 CKD patients. Results: Of 83 patients, prevalence of Vitamin D deficiency in Stage 3-5 CKD is 9.64%. The overall prevalence of low BAP, normal BAP, and high BAP in Stage 3-5 CKD is 3.61%, 74.70%, and 21.69%, respectively, was not statistically significant. Conclusion: Vitamin D deficiency is noted in earlier stages of CKD rather than late stages. BAP had statistically significant correlation with calcium, Vitamin D, and iPTH. Serum bone specific alkaline phosphatase assay should be included in CKD-MBD screening. The screening should begin in the early stage of CKD.
Authors and Affiliations
P Shankar, V Balaraman, B Praveen, Heber Anandan
Keywords
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