Profile of the adverse drug reactions among the multidrug resistant tuberculosis patients treated at a tertiary level hospital in southern India
Journal Title: IP Indian Journal of Immunology and Respiratory Medicine - Year 2018, Vol 3, Issue 4
Abstract
Background The prevalence of multidrug resistant tuberculosis MDRTB is increasing worldwide The treatment of MDRTB is challenging due to its delayed diagnosis prolonged duration of therapy with larger number of drugs coupled with their great potential for adverse drug reactions ADRs which severely impair treatment adherence Early identification and effective management of ADRs form the cornerstone to ensure treatment adherence which is an essential aspect in better treatment outcomeMaterials and Methods A prospective observational study was conducted for a period of 3 years at Basaveshwara Medical College and Hospital Chitradurga All MDRTB patients who fulfilled study criteria were included in study After pretreatment clinical evaluation necessary radiological serological and bacteriological investigations patients were treated by Cat IV regimen for MDR TB and monitored for development of ADRs and treated appropriatelyResults Mean age of patients was 38 36 years A 709 of patients had low body mass index BMI A 745 of patients got successfully cured ADRs were reported among 526 of patients GI intolerance 491 in intensive phase and psychiatric symptoms 418 in continuation phase were most common ADRs reported Low BMI was found to be significantly associated with ADRsConclusion Meticulous and regular followups with emphasis on early detection of ADRs during the course of ATT dosage adjustments to effectively manage ADRs addressing problem of malnutrition a compulsory psychiatrist opinion as part of pretreatment evaluation and also during continuation phase of ATT to detect the emergence of psychiatric symptoms will go a long way in achieving high rates of favourable outcomes among MDRTB patientsKeywords Adverse drug reactions Depression Suicidal tendencies Malnutrition Gastrointestinal intolerance
Authors and Affiliations
Rashmi B. M, Basavaraj Sangolli, Shruti Ghodageri, Sreeharsha Dr
Keywords
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- EP ID EP490614
- DOI 10.18231/2581-4222.2018.0040
- Views 70
- Downloads 0
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