Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by insulin resistance. Insulin resistance leads to hyperglycemia. Prolong hyperglycemia caused damaged organ and complication such as nephropathy (kidney), liver and cardiovascular diseases. Meanwhile, resistance insulin inhibits protein metabolism. This study aims to investigate the profile of protein organ kidney, liver and heart in T2DM rat animal model. This research was used rats group T2DM (DM) and normal rats as a control (C). Protein isolated from kidney, heart and liver. Profile profile analyzed by SDS-PAGE. In this study we found has different profile protein between T2DM rats (DM) and control rats (C). Fourty bands protein were found in 6 organs, there were HC 5 bands protein, HDM 8 bands protein, LiC 8 bands protein, LiDM 6 bands protein, KC 7 bands protein, KDM 6 bands protein. This result indicated that has different profile protein in rats group T2DM (DM) and rats control group (C).

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