Profiling of bioactive chemical entities in Barleria buxifolia L. using GC-MS analysis – a significant ethno medicinal plant
Journal Title: Journal of Ayurvedic and Herbal Medicine - Year 2017, Vol 3, Issue 2
Abstract
The present study was designed at to ascertain the plausible bioactive compounds of the aerial methanolic extract of Barleria buxifolia via GC-MS analysis which is used as a noteworthy ethnomedicinal plant for treating various diseases. The peaks perceived in the mass spectra were identified as compounds and were matched with the National Institute of Standards and Technology and Wiley library. Identified compounds were predicted for its activity using PASS software. Interestingly, about 30 compounds were scrutinized with their retention time, molecular formula, molecular weight, peak area (%). Based on structure, activities were predicted. The GC-MS analysis unveiled the different kinds of bioactive compounds such as alkaloids, terpenoids, triterpenoids, esters, aliphatic ketones, β-carotene etc. In bioinformatics approach, using the software, Prediction Activity Spectra for Substances (PASS), pharmacological effects and drug likeness were determined for all the compounds precisely which endorse the traditional usage of B. buxifolia for the treatment of various kinds of diseases such as anti-inflammatory, antiulcer, antihypertensive, antiviral, antiobesity, antidiabetic, caridioprotectant, vasoprotector, spasmolytic, respiratory analeptic, carminative etc. It is inferred that the putative hits obtained from B. buxifolia could potentially serve as a launching pad for a hit-to-lead a novel drug development. Barleria buxifolia, Acanthaceae, GC-MS analysis, PASS prediction, Drug likeness, Activity.
Authors and Affiliations
Tamil Selvi S, s. Jamuna, Sangeeth Thekan, S. Paulsamy
Keywords
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