Prognosis Factors of Soft-Tissue Sarcomas: A Retrospective Study of 50 Cases
Journal Title: Scholars Journal of Medical Case Reports - Year 2018, Vol 6, Issue 9
Abstract
Soft tissue sarcomas (STS) are malignant tumors of mesenchymal origin that originate in any connective tissue or body support tissue. They have 1% of adult malignancies and are much less common than benign tumors developed in the soft tissue. Our study examined 50 cases of soft tissue sarcomas managed by the trauma and orthopedics department B4 at the university hospital center Hassan II Fès, over a period of 05 years between 2013 and the end of 2017, whose purpose is to analyze different prognostic factors determining the risk of local recurrence and metastases. The average age of patients in our series is 50 years, the sex ratio is 01. The most common types in our study were synovial sarcoma, liposarcoma and leiomyosarcoma. High grades (II and III) are the most common. The localization in the lower limb is the most frequent and concern predominantly the thigh. Wide excision is the most used treatment. 24% required a therapeutic supplement by external radiotherapy. Chemotherapy was indicated in 52% of cases. The evolution finds 10% of clinical and radiological remission, 22% of local recurrences isolated, 26% of metastases mainly pulmonary, 08% of recurrences associated with metastasis. 07 patients were lost to follow-up and 10 deaths were found postoperatively in our study. The prognosis of soft tissue sarcomas is traditionally unfortunate; and may be aggravated by inadequate therapeutic management, hence the importance of multidisciplinary management. Tumor size, depth, histological type and grade, margin status, and adjuvant radiotherapy are the main prognostic factors for recurrence and metastasis of these tumors.
Authors and Affiliations
ZEROUAL Ismail, SENHAJI Said, KACIMI ALAOUI Mehdi, EL IDRISSI Mohamed, EL IBRAHIMI Abdelhalim, EL MRINI Abdelmajid
Keywords
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