Prognosis in Patients with Melanosis Coli; A Prospective Study

Journal Title: Istanbul Medical Journal - Year 2019, Vol 20, Issue 3

Abstract

Introduction: Melanosis coli is a benign lesion associated with the overuse of laxatives containing anthraquinone. The aim of this study is to determine whether melanosis recovers after the discontinuation of laxatives and whether this condition is associated with a higher incidence of colon polyps or cancer compared to the general population. Methods: Patients with confirmed melanosis coli were performed a repeat colonoscopy and biopsy 2 years later and their histopathological examination results were compared. Data on age, sex, the use of any medicinal laxative or herbals, the presence of findings after the discontinuation of laxatives, constipation, colon polyp, and the relationship with colon cancer were examined. The similarity of segments and their relationships in the first and control colonoscopies were investigated in cases detected to have melanosis coli. Results: All 104 patients included in the study were suffering from constipation. While the number of patients using laxatives or herbal tea was initially 96, it was 24 at the time of follow-up colonoscopy. Although the majority of subjects had discontinued laxatives, histological findings of melanosis coli persisted in 88 of 104 subjects. Mostly descending colon and rectum were involved. Conclusion: It is thought that the findings of melanosis coli disappear in about 6 months following the discontinuation of laxative drugs and herbal teas. However, it was detected in our series that while the macroscopic findings were mostly healed even in the follow-up after two years, microscopic findings of melanosis coli continued to remain. No relationship was found between melanosis coli and the development of colon cancer and polyp. In the present study, it was aimed to emphasize that melanosis coli’s becoming chronic and its creating a predisposition to colon cancer should be investigated with longer follow-ups and some herbal teas may cause a long-term change in the colon mucosa.

Authors and Affiliations

Aylin Hande Gökçe, Feridun Suat Gökçe

Keywords

Related Articles

Evaluation of the Effect of NQO1 C609T (rs1800566) Gene Variations in Philadelphia-negative Myeloproliferative Neoplasms in Turkish Population

Introduction: Philadelphia-negative myeloproliferative neoplasm (MPN) is a hematopoietic stem cell disorder consisting of essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) associated...

A New Biochemical Marker for the Differential Diagnosis of Epileptic Seizure Types: Ischaemia-modified Albumin

Introduction: This study aimed to evaluate the changes in ischaemia-modified albumin (IMA) levels in different types of hypoxia-associated epileptic seizures. Methods: A total of 80 patients admitted to the Neurology Ou...

Association between Mean Platelet Volume and Bone Mineral Density in Rheumatoid Arthritis

Introduction: This study aimed to evaluate the mean platelet volume (MPV) levels in rheumatoid arthritis (RA) and determine whether there is a relationship between MPV and bone mineral density (BMD) measurement. Methods...

Effect of Concha Bullosa on Skull Base

Introduction: To demonstrate the effect of concha bullosa (CB) on the height of the skull base. Methods: We retrospectively scanned the files of 1022 patients who had undergone paranasal sinus tomography for sinusitis i...

Cerebral Venous Thrombosis in Pregnancy

Introduction: Although not a prevalent disease, cerebral venous thrombosis (CVT) has been considered relatively morbid. There is little research about CVT in Iran, but it is more likely during pregnancy and puerperium. T...

Download PDF file
  • EP ID EP549177
  • DOI 10.4274/imj.galenos.2018.36043
  • Views 125
  • Downloads 0

How To Cite

Aylin Hande Gökçe, Feridun Suat Gökçe (2019). Prognosis in Patients with Melanosis Coli; A Prospective Study. Istanbul Medical Journal, 20(3), -. https://europub.co.uk/articles/-A-549177