Prognostic model for determining the probability of congenital pneumonia in full-term newborns
Journal Title: Здоров`я дитини - Year 2019, Vol 14, Issue 4
Abstract
According to the data of the World Health Organization, pneumonia is one of the leading causes of death in children under five years of age. Objective: to develop a prognostic model to determine the factors associated with the development of congenital pneumonia in full-term newborns. A comprehensive survey of 116 full-term newborns who were in the pediatric Department for newborn children and the Maternity Physiological Department of the State Institution “Republican Scientific and Practical Center “Mother and Child” in the period from 2017 to 2019 was conducted. The study group consisted of 53 healthy full-term newborns with congenital pneumonia, born at the gestational age of 39.50 ± 0.69 weeks, body weight 3337.50 ± 354.42 g and a body length of 52.20 ± 2.13 cm. The control group consisted of 63 healthy full-term babies born at gestational age of 39.30 ± 0.63 weeks, body weight 3417.30 ± 253.82 g and a body length of 52.50 ± 1.57 cm. The survey revealed the most significant factors associated with the development of congenital pneumonia in full-term newborns: from the obstetric-gynecological and somatic history of the mother’s life — spontaneous miscarriage; from the complications of pregnancy — chronic intrauterine fetal hypoxia; the placenta study determined the presence of inflammatory changes in the placenta; clinical manifestations within the first 72 hours of life included respiratory failure. Based on the data obtained, a model with sensitivity equal to 92.5 %, specificity 92.1 % and an area under ROC-curve (AUC) 0.94 ± 0.054, p < 0.001 (95% CI 0.90–0.99). Using a prognostic model, threshold values were calculated: for spontaneous miscarriage — 0.810; chronic intrauterine fetal hypoxia — 0.289; inflammatory changes in the placenta — 0.565; the presence of respiratory failure — 0.928, which at threshold values ≥ 0.56 ROC-curve allows identify a high risk group for the development of congenital pneumonia among full-term newborns.
Authors and Affiliations
A. N. Horiachko, A. V. Sukalo
Keywords
Related Articles
- EP ID EP613558
- DOI 10.22141/2224-0551.14.4.2019.174040
- Views 84
- Downloads 0
Fever of Unknown Origin in Children: Optimization of Diagnostic Search (Part I)
The first part of the article contains general data about fever of unknown origin, its etiological structure. There is provided the most important clinical information about infectious and oncological diseases, which ini...
New therapeutic opportunities of phytopreparations in the treatment of acute respiratory infections in children
We consider it is reasonable to use symptomatic therapy in all cases of uncomplicated acute respiratory viral infections, which are self-eliminating diseases. Herbal preparations is an important part of such treatment in...
Nosospecific features of redox processes in cystic fibrosis
The review of the literature presents current data on the characteristics of redox processes occurring in the respiratory tract in cystic fibrosis.
Features of Cytological Profile of Induced Sputum in School-Age Children with Exercise-Induced Bronchial Asthma
On the basis of Regional children’s clinical hospital of Chernivtsi, in 41 school-age children with persistent bronchial asthma (BA), the nature of airways inflammation has been studied with the aim of differential choic...
Endoscopic Features of Changes in Gastric Mucosa at Chronic CagA-positive Hр-associated Gastritis in Children
The article presents the results of the comparative analysis of standard endoscopy of the gastric mucosa in children with chronic Helicobacter pylori-associated gastritis taking into account cytotoxicity of Helicobacter...