Prognostic serum biomarkers for colorectal cancer – Review
Journal Title: Journal of Cancer Research & Therapy - Year 2018, Vol 6, Issue 1
Abstract
Background: Colorectal cancer (CRC) is one of the most common malignancies in developed countries. Research for diagnostic and prognostic biomarkers is increasing. There are more than 750,000 papers indexed in PubMed directly related to biomarkers. A lot of these papers claim to report clinically useful biomarkers. Unfortunately, very few serum biomarkers are in clinical use. Materials and methods: We performed a review for most of the published CRC serum biomarkers in the PubMed, Embase and Web of Science databases. Results: In total, 119 articles were obtained from the databases, of which 89 articles reporting on CRC serum prognostic markers were considered as relevant. In these studies, a total of 200 individual tumor markers were obtained. Conclusions: A general approach to understand how to predict clinical outcomes using risk, diagnostic, and prognostic biomarkers, is needed. In the future, serum biomarkers will drive advances in risk, diagnosis, and prognosis, they will be the targets of powerful molecular therapies, and they will individualize and optimize therapy.
Authors and Affiliations
Yovchev Y, Enchev E, Dimitrov E, Minkov G, Nikolov S
Keywords
Related Articles
- EP ID EP523083
- DOI 10.14312/2052-4994.2018-1
- Views 50
- Downloads 0
Changing trends in gastrointestinal malignancy in Indonesia: The Jakarta experience
Aims: To identify changing trends in gastrointestinal cancer incidence in Indonesia according to age, gender, histopathology, and cancer location. Methods: We examined retrospectively the demography, cancer location, and...
Apocrine carcinoma of the scalp – A case report and highlights for diagnosis
Apocrine sweat gland carcinoma is a rare cutaneous adnexal neoplasm that may occur in the scalp, eyelid, and ear canal. More often, it presents as an asymptomatic, slow-growing, solid or cystic mass with variable color....
Colitis and chronic bleeding in patients treated with dasatinib
Dasatinib is a key therapeutic option in patients with chronic myeloid leukemia. Previous case reports associated it with acute colitis. This is another report that demonstrates a link between dasatinib and chronic colit...
Intra-observer agreement in single and joint double readings of contrast-enhanced breast MRI screening for women with high genetic breast cancer risks
Objectives: To examine intra-observer reliability (IR) for lesion detection on contrast-enhanced breast magnetic resonance images (MRI) for screening women at high risk of breast cancer in single and joint double reading...
Hyperpigmentation of the tongue, palms and soles: Rare side effect of capecitabine
Cutaneous side effects of capecitabine include hand foot syndrome which manifests as erythema, swelling and/or desquamation. We report a case on capecitabine treatment presenting with unusual hyperpigmentation of the ton...