Prognostic Signicance of Cellular Iron Metabolism in Breast Cancer
Journal Title: Pakistan Biomedical Journal - Year 2018, Vol 1, Issue 1
Abstract
Breast carcinoma is among the most common malignancy in women. Abstract: Objective: Aim of the present study was to evaluate the prognostic signicance of iron expression in the biopsies of patients with breast cancer Methods: 24 breast biopsies were studied. 19 cases were poorly differentiated, 5 cases were moderately differentiated and there was no well differentiated case. Iron, Estrogen receptor (ER), Progesterone receptor (PR), HER2 and Ki-67 immunohistochemical staining was performed for all these Results: Among the 5 moderately differentiated cases, 3 (60%) were positive for iron staining and among 19 poorly differentiated cases, 11 cases (57.89%) were positive. More iron positive cases (7 out of 14) were triple positive belonging to Luminal B class. Out of 14 iron positive cases, 11 were positive for HER2, 10 for ER, 9 for PR and all positive for Ki-67. conclusions; Iron deficiency in premenopausal and overload in post-menopausal women can contribute to the development of breast carcinoma. So, iron can be considered as a cheap and effective marker for the prognosis of breast cancer. Association between a rise in iron levels and HER2 expression may provide new strategy for breast cancer treatment.
Authors and Affiliations
Rizwan Ullah Khan*, Amber Hassan, Imrana Tanvir and Kashifa Ehsan
Keywords
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- EP ID EP694161
- DOI https://doi.org/10.52229/pbmj.v1i1.35
- Views 135
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