Prognostic significance of soluble ST2 as predictor of late left ventricular remodeling after ST-segment elevation myocardial infarction
Journal Title: Серце і судини - Year 2018, Vol 0, Issue 4
Abstract
The aim — to study the prognostic value of soluble ST2 regarding the development of pathological left ventricular remodeling (LVR) 6 months after acute ST‑ segment elevation myocardial infarction (STEMI) Materials and methods. The study included 65 retrospectively selected patients with STEMI who were hospitalized in the intensive care unit of L. T. Malaya National Institute of Therapy of National Academy of Medical Sciences of Ukraine for the period from January 2016 to June 2018 after myocardial revascularization. All patients had a recovery in TIMI III blood flow. Among the patients, men with a middle age 58.71 ± 11.04 years (83.1 %) prevailed. Ultrasound diagnosis with the determination of the longitudinal strain was conducted. The level of sST2 and N‑terminal cerebral natriuretic peptide was determined by ELISA. Patients were monitored for 6 months. According to the results of the re‑examination, two subgroups were identified, depending on the development of pathological LVR: in the first group, the increase in the endodiastolic LV volume was more than 10 % (n = 29), in the second — less than 10 % (n = 36). Results and discussion. Using ROC‑analysis, it was established that sST2 level > 35 ng/ml during the hospitalization period of STEMI is a predictor of pathological LVR 6 months after successful percutaneous coronary intervention (AUC = 0.672; 95 % confidence interval — 0.523 — 0.799, p = 0.0344, sensitivity — 46.7 %, specificity — 85.7 %). A single and multivariate log‑regression analysis revealed that sST2 > 35 ng/ml was an independent predictor of the development of late LVR. Conclusions. The serum sST2 level of more than 35 ng/ml in patients with STEMI after successful percutaneous coronary intervention with the bloodstream in the infarct‑dependent artery TIMI III is associated with abnormal LVR, which can be used to stratify its risk in this cohort of patients.
Authors and Affiliations
O. V. Petyunina, M. P. Kopytsya, A. E. Berezin
Keywords
Related Articles
- EP ID EP451947
- DOI 10.30978/HV2018-4-89
- Views 144
- Downloads 0
Phenotype-oriented approach to clinical evaluation of patients with chronic heart failure with preserved left ventricular ejection fraction
The aim — to establish the clinical significance of the phenotype‑based approach to assessing patients with verified heart failure (HF) with preserved left ventricular (LV) ejection (LV) fraction and its relationship wit...
Assessment of frequency of cranial nerve lesions after carotid artery surgery
The aim — to improve the methods of treatment of carotid pathology by analyzing the frequency of the cranial nerves’ lesions through generalization of the literary sources and the results of own observations. Materials...
Surgical treatment of hypertrophic cardiomyopathy: what’s new?
The aim — to investigate the effectiveness of surgical septal myectomy in patients with obstructive form of hypertrophic cardiomyopathy (HCM) and to determine its effect on survival and quality of life. Materials and me...
Prevention of cardiac events in perioperative period in patients with acute calculous cholecystitis and coronary heart disease
The aim — to evaluate the effectiveness of the advanced therapy for the prevention of cardiac complications in the pre, intra and early postoperative period in patients with acute calculous cholecystitis (ACC) and coro...
Complex assessment of severity and clinical functional status in adults with congenital heart disease
The aim — to estimate the severity and clinical functional status in adults with congenital heart disease (ACHD). Materials and methods. The study included 456 consecutive adults with CHD who were admitted to Scientific...