Prognostic Value of Cardiac Biomarkers in Hemodialysis Patients – which one to use?
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
The high prevalence of cardiovascular mortality in the end-stage renal disease population is well established. The aim of this current study was to document the relative prognostic significance of established biomarkers high-sensitive cardiac troponin T (hs cTnT), cardiac troponin I (cTnI), and N-terminal proBNP (NT-proBNP) and high-sensitive CRP (hs CRP) in this population. A prospective cohort study of dialysis patients undertaken in a single centre in Bulgaria. The relation between mortality and cardiac biomarkers was evaluated in 140 hemodialysis patients. End-point of interest was cardiac mortality. Statistical analysis using Cox proportional hazards was used to study relationship between competing covariates and outcome. Patients was followed upor a median duration of 24 months. The mean concentrations (+/-SEM) of hs cTnT, cTnI, NTproBNP and hs CRP were 0,07±0,01 µg/L, 0,03±0,01 µg/L, 14969±1125 pg/mL and 16,4±2,38 mg/L respectively. Thirty-six subjects died during the period of follow up. By univariate analysis, cardiac markers hs cTnT, cTnI and NT-proBNP were significantly associated with an increase mortality. On Cox proportional hazards analysis, hs cTnT showed a highest significant association with cardiac mortality, with hazard ratios of 2,46, 95% confidence interval (CI) 1,39-4,33, p<0,002, followed by cTnI- 1,82, 95% CI1,41-2,34, p<0,0001 and NT-proBNP - 1,78, 95% CI 1,28-2,48, p<0,001 respectively. In patients with end-stage renal failure on dialysis hs cTnT provides greater prognostic information compared with NT-proBNP and cTnI.
Authors and Affiliations
R. Koycheva, M. Penev, Sv. Staykova
Keywords
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- EP ID EP369817
- DOI 10.9790/0853-1703137682.
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