Prognostic Value of Epidermal Growth Factor Receptor in Colorectal Carcinoma
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 3
Abstract
ABSTRACT Introduction: Colorectal carcinoma is a common malignancy with a worldwide distribution. AJCC tumour staging is the single most important prognostic indicator which is also used for selecting cases for postoperative adjuvant therapy. However, a considerable number of curatively treated colon cancer patients ultimately develop disease recurrence prompting the need to identify additional prognostic markers. Extensive research into the biology of colorectal cancer has identified some molecular markers such as Epidermal Growth Factor Receptor (EGFR) which, in addition to providing an insight into the carcinogenesis of colorectal carcinoma, also provide prognostic information. Aim: To evaluate the prognostic value of expression of EGFR in colorectal carcinoma by correlating it with established prognostic markers such as grade and stage of the tumour. Materials and Methods: Retrospective cohort study of 100 cases of colorectal carcinoma who underwent radical surgery at a large tertiary care hospital was done. Relevant clinical data of the cases was collected from medical records. Histopathologic evaluation of tumour grade, depth of invasion, number of lymph nodes involved and pathologic stage was done. Immunohistochemistry (IHC) was performed for assessment of EGFR expression, which was categorised as positive if >1% of the tumour cells showed EGFR immune-specific membranous brown staining. Expression of EGFR was correlated with the tumour site, histological grade and the pathologic stage by chi-squared test (χ2). Values were considered significant at p<0.05. Results: Among the stage I and stage II tumours, 18% and 31%, respectively, were positive for EGFR, while among the stage III and stage IV tumours, 74% and 80%, respectively, were positive for EGFR. A highly positive and significant correlation (p<0.01), along with a linear association was noted between the pathologic stage and the EGFR expression of the tumours. No significant association was noted between either the expression of EGFR and the histological grade (p=0.51) or the expression of EGFR and the site of tumour (p=0.10). Conclusion: Epidermal growth factor receptor, due to its strong correlation with the pathologic stage of colorectal carcinoma, can be of prognostic significance. This may have a role in selecting those patients who are at high risk for disease progression and therefore are likely to benefit from adjuvant therapy.
Authors and Affiliations
Anamika Sinha, Sukumar Santosh Kumar
Keywords
Related Articles
- EP ID EP511805
- DOI 10.7860/JCDR/2018/34864.11234
- Views 71
- Downloads 0
The Spectrum of Heart Disease in Pregnancy and its Outcome in Patients Visiting a Tertiary Care Centre of Northeastern: A Prospective Study
Introduction: An increased prevalence of cardiovascular disease has been found in women of child bearing age which varies between 0.3-3.5%. Heart diseases are the most significant non obstetrical causes of maternal death...
Music Induced Emotion and Music Processing in the Brain– A Review
ABSTRACT Music has been a constant source of fascination and constitutes the major and oldest socio-cognitive fields of the human. Music is considered to be the strongest stimulus to induce human emotion and also has the...
Symptomatic Remission in Schizophrenia and its Relationship with Functional Outcome Measures in Indian Population
Introduction: Schizophrenia is a chronic mental disorder with disabling symptoms and variable outcome. Outcome is a multidimensional construct that depends on description of clinical and social domains. Symptomatic remis...
Prediction of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) after Thoracic Surgery: The Role of Estimated GFR
Introducton: Little is known about the prognostic utility of preoperative estimated GFR (eGFR) on perioperative Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) in apparently lower risk patients undergoing...
Pattern of Self Prescribed Analgesic Use in a Rural Area of Delhi: Exploring the Potential Role of Internet
Introduction: Analgesics are the most common self prescribed drugs. Although considered to be relatively safe, side effects are often seen when these drugs are used for prolonged period, in high doses or used where contr...