Prognostic Value of Platelet to Lymphocyte Ratio in Patients with Non-Small Cell Lung Cancer
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 9
Abstract
<strong>Background: </strong>The prognostic value of Platelet-to-lymphocyte ratio (PLR) in patients with non-small-cell lung cancer (NSCLC) is still indistinct. We conducted this study to assess the prognostic significance of pretreatment PLR in patients with unresectable NSCLC.<br /> <strong>Aim of the Work: </strong>to assess the prognostic significance of pre-treatment PLR in patients with NSCLC.<br /> <strong>Material and Methods: </strong>we retrospectively reviewed 130 patients treated for NSCLC with definitive/palliative chemotherapy and/or radiotherapy in Ain-Shams University hospital, Clinical Oncology department between January 2014 and December 2016. Pre-treatment CBC was available for the 130 patients to calculate PLR by dividing the absolute platelet count by the absolute lymphocytic count.<br /> <strong>Results: </strong>Out of 130 patients with available pre-treatment complete blood picture, population age ranged from 23 to 87 years. Male to female ratio was 4.8:1. Adenocarcinoma presents 51% of cases. Unresectable stage II and stage III present 2% and 27% respectively, while Stage IV presents 69%. Using a cut-off value of 150, high PLR>150 was significantly associated with poor overall survival (OS) (median OS: 10.33 months; 95% CI: 6.23-14.42), compared to patients with PLR<150; (median OS: 24.63 months, 95% CI: 11.5-37.76, p=0.008), but not PFS. In multivariate analysis, PLR>150 was an independent poor prognostic factor for OS; (HR=1.9, 95% CI; 1.092-3.3, p=0.023). <br /> <strong>Conclusion: </strong>High PLR is associated with poor OS in patients with unresectable NSCLC.
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584325
- DOI 10.12816/ejhm.2018.11166
- Views 120
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