PROGNOSTIC VALUE OF PRETREATMENT CA 125 IN PATIENTS OF OVARIAN CARCINOMA.
Journal Title: Journal of Indira Gandhi Institute of Medical Sciences - Year 2019, Vol 5, Issue 1
Abstract
ABSTRACT: Introduction- In patients with epithelial ovarian cancer (EOC) , the volume of residual tumour after debulking is the prognostic factor for survival. We examined the relationship between postoperative decline in serum cancer antigen(CA125) and residual disease after cytoreductive surgery and evaluate post operative changes in serum CA125 levels as predictor for disease-specific survival. Material and methods-This retrospective study consisted of evaluation of serum CA125 in 173 patients with EOC treated with cytoreductive surgery, either primary or secondary surgery after neoadjuvant treatment between June 2015 and Jan 2018 in a tertiary care centre of Bihar. Preoperative and postoperative CA125 value were recorded and simultaneous diagnosis of histological subtype, clinical stage and differentiation grade of the tumour (n=173) were studied in order to determine the prognostic value of CA125. Result- We found irresectable mass in 58 EOC patients out of which 56(96.55%) had preoperative CA125 >500 [p <0.001]. A postoperative decline in serum CA125 level of ≥80% was associated with complete primary cytoreduction (p=0.035). On analyses there was favorable associations with survival for both the degree of decline in serum CA125 and residual tumor after primary cytoreduction [p < 0.001]. Conclusion-The current retrospective study suggests that the preoperative CA125 value determine the resectability of ovarian mass and also post operative decline in serum CA125 is an early biomarker that predicts disease-specific survival in patients who underwent cytoreductive surgery for EOC.
Authors and Affiliations
Jaya Kumari
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