Prognostyczne znaczenie aktywności kinazy tymidynowej u chorych na przewlekłą białaczkę limfocytową
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue
Abstract
Authors and Affiliations
Piotr Stelmach, Jerzy Z. Błoński, Ewa Wawrzyniak, Paweł Schweiger, Artur Wilandt, Tadeusz Robak
Molecular bases of cellular senescence: Hayflick phenomenon 50 years later
Normal human somatic cells have strictly limited proliferative capacity and reach a state of senescence when it becomes exhausted. It is believed that senescence is a response to extensive and irreparable DNA injury, loc...
BRAF mutation in progression and therapy of melanoma, papillary thyroid carcinoma and colorectal adenocarcinoma
BRAF is mutated at a high frequency in various malignancies, including melanoma, papillary thyroid carcinoma and colorectal adenocarcinoma. BRAF is an element of the RAS/RAF/MEK/ERK (MAPK) pathway, which when constitutiv...
Effects of endogenous cardioprotective mechanisms on ischemia-reperfusion injury
Ischemic heart disease have been remarked as a leading cause of morbidity and mortality in adults. Early restoration of cardiac perfusion is necessary to restore perfusion of ischemic heart muscle. Effective revasculariz...
Role of protein disulfide isomerase in activation of integrins
Integrins belong to a large family of transmembrane cell adhesion receptors that communicate biochemical and mechanical signals in a bidirectional manner across the plasma membrane. Integrins and their ligands play a cru...
Role of Porphyromonas gingivalis in rheumatoid arthritis and inflammatory spondyloarthropathies
The most recent studies confirm the link between rheumatoid arthritis (RA) and periodontal disease. RA patients have higher prevalence of chronic periodontitis and periodontal disease is often more severe in these patien...