Progress on mTOR in eye diseases
Journal Title: Eye Science (Yanke Xuebao) - Year 2024, Vol 39, Issue 1
Abstract
Mammalian target protein of rapamycin (mTOR) is a protein kinase that primarily involves in the regulation of nutrient levels and growth metabolism in vivo. mTOR serves as a crucial target for cancer, aging, and other metabolic related pathological diseases, participating in various biological processes such as proliferation, transdifferentiation, and autophagy. The eye is considered an area with immune privilege, as the vascular system affects vision and is located outside the central light path. Many areas in the eye have mechanisms for transporting immune cells to the affected areas related to developmental, damaged, or aging. Although the immune response is primarily aimed at repairing or protecting itself, immune cells may secrete some cytokines, leading to inflammation or fibrosis, which in turn can damage vision. Results from studies have confirmed that mTOR is closely related to pterygium, age-related macular degeneration (AMD), glaucoma, cataract, diabetic retinopathy (DR), eye tumors and other eye diseases. Currently, mTOR inhibitors are widely used as immunosuppressants and approved for cancer treatment; however, there are few reports on the use of mTOR inhibitors for eye diseases. Therefore, in the article it provides a brief overview of the role, regulatory mechanisms, and drug treatment of the mTOR signaling pathway in related ophthalmic diseases, providing ideas for the pathological mechanisms and treatment of related ophthalmic diseases, in order to carry out more in-depth research in the future.
Authors and Affiliations
Yun HUA, Xinrong ZHAO
Keywords
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