Progress on the impact of lipid metabolism reprogramming on resistance to epidermal growth factor receptor tyrosine kinase inhibitors in nonsmall cell lung cancer
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 1
Abstract
Non-small cell lung cancer (NSCLC) is the main type of lung cancer, accounting for 85% to 90% of cases. The use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has greatly improved the prognosis of NSCLC patients. However, with prolonged drug use, the inevitable occurrence of acquired resistance leads to disease recurrence, progression, and even patients death. Metabolic reprogramming is one of the hallmarks of malignant tumors and refers to metabolic changes in tumor cells to meet energy needs. In various cancers, lipid synthesis, distribution, and catabolism of tumor cells are altered to adapt to the lack of nutrients and oxygen in the tumor microenvironment. This paper focuses on how lipid metabolism reprogramming in NSCLC leads to resistance to EGFR-TKIs and how modulation of lipid metabolism increases the sensitivity of NSCLC to EGFR-TKIs. It summarizes and consolidates existing research progress to provide a reference for basic research and clinical treatment of EGFR-TKIs resistance in NSCLC.
Authors and Affiliations
XIAO Xinyao, GUO Shunyao, LU Haiyan, SHEN Hua
Keywords
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- EP ID EP734644
- DOI 10.13429/j.cnki.cjcr.2024.01.001
- Views 68
- Downloads 0
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