Prolactin: An Emerging Prognostic Marker in Breast Cancer
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 8
Abstract
Introduction: The outcome for women with breast cancer varies widely, so it becomes increasingly important that the clinician is provided with accurate prognostic information on which to base the therapeutic decision. Some bio-chemical prognostic markers like hormones & tumor markers are use for prognostic purposes, yet need to be established as independent prognostic marker. Prolactin, a peptide hormone, has a role in carcinogenic process of the breast. Some studies have shown that there was a significant correlation between the serum concentration of prolactin before treatment and time and size of metastasis. Aim: We undertake this study to find out levels of serum prolactin in breast cancer patients and to compare their levels in early and in locally advanced breast cancer. Materials and Methods: The prospective study of 50 patients of proven breast cancer patients was included in this study whose TNM stage and a baseline serum levels was detected. Results: This study found that 32% cases had raised level of Prolactin out of which 81.8% were in locally advanced stage. Baseline Prolactin levels was more raised in locally advanced breast cancer than in early breast cancer cases (39.39%, than the early one 17.65%). The Odds of finding late stages in patients with Prolactin >=19 ng/ml was 3.0 times higher as compared to those with lower prolactin levels. Conclusion: Results point towards hypothesis that pre-operative prolactin levels can be used to predict tumor burden as levels could be related to poor outcome with possibility of micro-metastases thereby predicting type of surgery or adjuvant or neo-adjuvant therapy required.
Authors and Affiliations
Dr Manisha Jain
Keywords
Related Articles
- EP ID EP373546
- DOI -
- Views 74
- Downloads 0
Mothers’ Attitude and Practices on Breast Feeding in Sokoto, North-Western Nigeria
Background: Although the benefits of breastfeeding (BF) are well established, a number of traditional and cultural practices still affect the sustenance of appropriate breastfeeding. Inappropriate breast feeding practice...
Relation of Type 2 Diabetes and Hemoglobin with Auditory Acuity
Introduction: Diabetes-related sensorineural hearing impairment affects people’s ability to hear and understand sounds. This is a case control study with the purpose of determining the hearing loss in type II diabetes me...
Effect of Pilates Training Program on Balance in Participants with Idiopathic Parkinson’s Disease - an Interventional Study
Background and Purpose: Parkinson’s disease is a chronic progressive neurodegenerative disorder of insidious onset, characterized by the predominantly motor symptomatology associated with a diversity of non-motor symptom...
Oral Health Knowledge, Attitude and Practice and Its Relation to Oral Health Status among 12-Year Old School Children of Sullia Taluk
Introduction: Good oral health practices are necessary from an young age to ensure positive long term dental health and hygiene and the oral health of children is important towards their overall well being. Objectives: T...
A Study to Assess the Effectiveness of Self Instructional Module for Improvement in Quality of Life of Breast Cancer Patients
Introduction: The mortality and morbidity due to breast cancer has been a concern in the health care settings. Breast cancer is the most common form of cancer in females which requires early diagnosis and intervention....