PROLACTIN LEVELS BEFORE AND AFTER ELECTROCONVULSIVE THERAPY AND ITS CORELATION WITH CLINICAL IMPROVEMENT IN PSYCHOPATHALOGY
Journal Title: GJRA-Global Journal For Research Analysis - Year 2018, Vol 7, Issue 7
Abstract
BACKGROUND: It is a well-known fact that prolactin increases after Electroconvulsive Therapy (ECT), but in later studies it was found that the amount of prolactin rise after each ECT gradually declines on successive ECT. Many studies have found that there is a correlation between this prolactin drop and improvement in psychopathology. But the results found were inconsistent and only limited to depression. AIM: To see the serum prolactin changes during a course of ECT in patients suffering from BPAD mania and to assess whether any correlation exists between these changes and improvement in psychopathology. METHORD: 20 inpatients meeting diagnostic criteria for BPAD mania as per ICD-10 who were planned to receive ECT were taken as cases and 20 BPAD mania patients not receiving ECT were taken as controls. Blood for prolactin and psychopathology on YMRS assessed three times in each case. First at baseline, second after 1st ECT and third after last ECT. Similarly controls were assessed at baseline and after three weeks for prolactin and psychopathology. RESULTS: In patients who received ECT, serum prolactin levels were significantly raised after 1st ECT (mean 78.65) compared to baseline (mean 54.02). Prolactin level significantly decreased after a course of ECT (mean 67.22). There was no significant correlation between prolactin changes and in YMRS score. CONCLUSION: There is no significant correlation between prolactin changes during a course of ECT and improvement in psychopathology in BPAD mania patients suggesting the prolactin rise may be an epiphenomenon to ECT rather than reflection of therapeutic process.
Authors and Affiliations
Dr. Shalini Bijali, Dr D. Ram, Dr. S. K. Munda, Dr. Vikalp Wasnik
Keywords
Related Articles
- EP ID EP457844
- DOI -
- Views 89
- Downloads 0
Faculty - S. K. School of Business Management, Hemchandracharya North Gujarat University, Patan-384265
Social media is a controversy topic in today's society. Social media makes human interaction much more convenient and much faster than real life human interaction, it makes globalization a reality, it gives a chance for...
BILATERAL PERSISTENT SCIATIC ARTERIES (PSA) AND VARICOSE VEINS: MRI DEMONSTRATION OF AN UNUSUAL ASSOCIATION
Persistent sciatic artery (PSA) is an extremely rare anatomical variant of lower limb arterial supply with an incidence of 0.025-0.6 % as estimated on angiographic studies. This vessel is prone for atherosclerosis, aneur...
HELICOBACTER PYLORI INFECTION AND ITS ASSOCIATION WITH HISTOMORPHOLOGICAL CHANGES IN THE GALL BLADDER OF PATIENTS WITH CHRONIC CHOLECYSTITIS
Role of H.pylori in chronic gastritis, peptic ulcers, gastric carcinoma and malignant lymphoma of gastric mucosa associated lymphoid tissue (MALToma) is well established. However its role in gall bladder diseases is stil...
INDIAN COMMODITY MARKETS AND THEIR RELEVANCE TO THE ECONOMY
It is unfortunate that in a predominantly agrarian economy like India, the full potential of commodity markets remains unrealised. Hedgers are unhappy with the hedging efficiency of our commodity exchanges although they...
FACTORS INFLUENCING THE FARMERS TO AVAIL AGRICULTURE CREDIT SANCTIONED BY VARIOUS FINANCIAL INSTITUTIONS IN SIVAGANGA DISTRICT
Agriculture credit plays an important role in the development of the Indian economy. The prosperity of the country depends up on the agriculture sector. Bankers play a major role in providing agricultural credit to the f...