Proliferative Indices (MIB-1) in Meningiomas: Correlation With The Histological Subtypes and Grades
Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 4
Abstract
We examined the proliferative potentials of meningiomas in 87 patients using the MIB-1 antibody against the Ki-67 antigen and compared them with the histopathologic subtypes and grades. Values of MIB-1 labeling indices (LIs) seem to parallel degree of histologic malignancy in many tumors, including meningioma. The growth potential of meningiomas is variable. MIB-1 LI of meningiomas is correlated with regrowth potential and tumor doubling time. In our study, histological grading of the meningiomas according to the latest World Health Organization clasification included the cases of 49 grade I, of 31 grade II, and of 7 grade III. The mean ± SD MIB index was 2.23±2.31 in grade I meningiomas, and those of grade II and grade III meningiomas were 6.53±5.31 and 11.1±7.8, respectively. There was a correlation between the values of MIB-1 LI and the histological grades. Meningiomas have also a wide range of histopathological appearances. Some differences for MIB-1 labeling indices were found among the subtypes of meningiomas of same grade. Results were analyzed using statistical methods and discussed.
Authors and Affiliations
Pınar KARABAĞLI, Aydın SAV
Keywords
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