Promising New Target in the Treatment of Diseases: FOXO Transcription Factors
Journal Title: Hippocrates Medical Journal - Year 2022, Vol 2, Issue 1
Abstract
Cells have evolved elaborate mechanisms to survive or coordinate the cellular response to apoptosis. Forkhead box-O transcription factors (FOXOs); It plays critical roles in the execution of various cellular processes by regulating the expression of genes involved in DNA damage repair, cell cycle progression and arrest, oxidative stress response and redox signaling, gluconeogenesis and apoptosis. Function of FOXO transcription factors; It is tightly controlled by post-translational modifications such as phosphorylation, acetylation and ubiquitination, and nuclear cytoplasmic transition. Made works; It shows that the regulatory effect of FOXO activity occurs in response to different stimuli, including oxidative stress. Abnormalities in post-transcriptional modification of FOXO transcription factors are frequently associated with various disease states. In this study; In order to present new research ideas to scientists, the definition and classification of FOXO transcription factors, post-transcriptional FOXO modifications under various physiological and pathophysiological conditions, including oxidative stress and cancer, and the clinical use of FOXO's tumor suppressor properties as therapeutics were investigated and compiled in the light of literature.
Authors and Affiliations
Nihal VURANOK
Keywords
Related Articles
- EP ID EP708988
- DOI 10.29228/HMJ.11
- Views 56
- Downloads 1
The Effects of Behçet’s Disease on LUTS in Male Patients
Abstract Objective In this study, we aimed to evaluate the relationship between Behçet's disease (BD) and lower urinary tract symptoms (LUTS). Materials and Methods In june 2019 to 2021, 56 male patients who...
Struma ovarii presented with pseudo-Meigs' syndrome: a case report and review of the literature
Abstract Pseudo-Meigs' syndrome is a clinical condition characterized by ascites and pleural effusion, accompanied by pelvic tumors other than ovarian fibroma. Struma ovarii is a tumor that can lead to this syndrome and...
Promising New Target in the Treatment of Diseases: FOXO Transcription Factors
Cells have evolved elaborate mechanisms to survive or coordinate the cellular response to apoptosis. Forkhead box-O transcription factors (FOXOs); It plays critical roles in the execution of various cellular processes by...
A Case of Myocarditis Related to Salmonella Enteritis Presenting with Acute Coronary Syndrome Clinic
Myocarditis is most often caused by a viral infection, it has also been shown that it is sometimes associated with bacteria. Myocarditis associated with gastrointestinal infections is rare and its pathogenesis has not be...
Clinical Approach to Obesity in Primary Care
Obesity is a multifactorial and multisystemic pathogenic condition that causes an increased risk of many diseases. As one of the major causes of preventable deaths, it also heavily features among the leading health probl...