Properties of tropolone/γ-cyclodextrin complexes prepared using different methods
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 9
Abstract
The aim of the present study is to evaluate the properties of the inclusion complex of tropolone (TPN)/γ-cyclodextrin (γCD) prepared by cogrinding method and coprecipitation method. The physical properties of the preparation were evaluated by differential scanning calorimetry, powder X-ray diffraction, infrared absorption spectra, and 1H-1H NOESY NMR spectrum. Intermolecular interactions in the solid state were confirmed to be in the molar ratios TPN/γCD = 2/1 and TPN/γCD = 4/1 in the cogrinding method and molar ratio TPN/γCD = 2/1 in the coprecipitation method. In addition, in GM (TPN/γCD = 4/1), two molecules of TPN were encapsulated in the molecular space formed between γCD. Therefore, it was suggested that different inclusion structures of TPN/γCD complexes were formed using different preparation methods
Authors and Affiliations
Dr. Yutaka Inoue
Keywords
Related Articles
- EP ID EP331132
- DOI -
- Views 89
- Downloads 0
An observatory study about Diabetic Screening and Counseling OPD
Diabetes is one of the most costly and burdensome chronic diseases of contempraroy era. Individuals with type 2 diabetes are also at a significantly higher risk for coronary heart disease, peripheral vascular disease, hy...
Antimicrobial Resistance Pattern of Clinically Significant Microorganisms Isolated from Dhaka, Bangladesh
Infectious diseases are the most common health problems. Diagnosis and treatment of the bacterial diseases are ambiguous, especially in Bangladesh. Though the present condition of health care settings in Bangladesh has i...
Synthesis of 3-pyridyl [1, 2, 4] triazolo [3, 4-b] [1, 3, 4] thiadiazepines and evaluation of their antibacterial and antifungal activities
Some novel 3-pyridyl [1, 2, 4] triazolo [3, 4-b] [1, 3, 4] thiadiazepines derivatives were synthesized from substituted 4-amino 5-pyridine- 3-yl-1, 2, 4 triazole 3-thiol and substituted chalcones in the presence of glaci...
In silico drug designing studies on dengue virus envelope protein
The key proteins involved in causing dengue are seven major proteins, which are considered as major therapeutic targets for dengue drug development. Recent studies have reported positive for dengue virus envelope protein...
Skimmed milk mediated solubility enhancement of loperamide and development of mouth dissolving tablet
Purpose of current research work was to develop mouth dissolving tablets of Loperamide HCl with enhanced solubility and palatable taste. Mouth dissolving tablets of Loperamide HCl were prepared by the direct-compression...