PROPHYLACTIC EFFECT OF CAMEL MILK AND SILYMARIN ON PHYSIOLOGICAL AND BIOCHEMICAL CHANGES IN CCL4-INTOXICATED RATS
Journal Title: Journal of Experimental Biology and Agricultural Sciences - Year 2018, Vol 6, Issue 1
Abstract
Present study has been carried out evaluate prophylactic effect of Camel milk on physiological and biochemical changes in CCl4-intoxicated rats. A total of 36 male albino rats were randomly divided into 6 groups viz. control group (G1), silymarin (SM) group (G2), camel milk (CM) group (G3), CCl4-intoxicated group (G4), silymarin prophylactic group (G5) and camel milk prophylactic group (G6). Each group has six rats. After completion of the study (8 wks), blood samples were collected and hematological parameters, liver contents of glutathione (GSH), malondialdhyde (MDA) , superoxide dismutaseactivity (SOD), serum urea, uric acid, creatinine, testosterone, estradiol were measured. The results of this study revealed that CCl4 toxicity significantly reduced Hb level, RBCs count and PCV, whereas it significantly increased the WBCs count with respect to normal control. Intoxication of CCl4 in G4 rats led to microcytic hypochromic anaemia, increased erythrocyte fragility and, leukocytosis was accompanied neutrophils increases and a decrease in lymphocyte counts. Also, CCl4 produced significant increase in serum urea, uric acid, creatinine and estradiol level and decrease in circulating testosterone level compared with normal rats. Pre-treatment with CM and SM brought significant restoration in hematological, renal function parameters and sexual hormones disturbance. Moreover, lipid peroxidation and oxidative stress were obviously noted in CCl4 intoxicated (G4) organism where a significant increase in liver MDA and decrease in its content of GSH and SOD activity. Contrarily, pre-treatment with CM and SM did not only decrease liver content of MDA but also increased hepatic GSH and SOD activity, suggesting that CM and SM attenuated CCl4-induced oxidative stress. In conclusion, CM and SM had a considerable prophylactic effectiveness against hematotoxicity, oxidative stress, lipid peroxidation, renal impairment and sexual hormones disturbances developed by intraperitoneal injection of rats withCCl4.
Authors and Affiliations
Zahran F, Gabr SA, Abd El-Moneim AE, Sharoud MN, Hassanin , WF , Mesalam NM
Keywords
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